Synthesis, Characterization and in vitro Studies of a Cathepsin B‐Cleavable Prodrug of the VEGFR Inhibitor Sunitinib

Since several decades, the prodrug concept has raised considerable interest in cancer research due to its potential to overcome common problems associated with chemotherapy. However, for small‐molecule tyrosine kinase inhibitors, which also cause severe side effects, hardly any strategies to generat...

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Detalles Bibliográficos
Autores principales: Karnthaler‐Benbakka, Claudia, Koblmüller, Bettina, Mathuber, Marlene, Holste, Katharina, Berger, Walter, Heffeter, Petra, Kowol, Christian R., Keppler, Bernhard K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391952/
https://www.ncbi.nlm.nih.gov/pubmed/30566287
http://dx.doi.org/10.1002/cbdv.201800520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391952/
https://www.ncbi.nlm.nih.gov/pubmed/30566287
http://dx.doi.org/10.1002/cbdv.201800520

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