Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding

A variety of methods have been employed to study the impact of posttranslational modifications on Tau protein function. Here, a semisynthesis strategy is described that enables selective modification within the central repeat domain of Tau4 (residues 291‐321), comprising a major interaction motive w...

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Detalles Bibliográficos
Autores principales: Ellmer, Doris, Brehs, Manuel, Haj‐Yahya, Mahmood, Lashuel, Hilal A., Becker, Christian F. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391969/
https://www.ncbi.nlm.nih.gov/pubmed/30549369
http://dx.doi.org/10.1002/anie.201805238

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