Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype

Most genes mutated in microcephaly patients are expressed ubiquitously, and yet the brain is the only major organ compromised in most patients. Why the phenotype remains brain specific is poorly understood. In this study, we used in vitro differentiation of human embryonic stem cells to monitor the...

Descripción completa

Detalles Bibliográficos
Autores principales: Javed, Attya Omer, Li, Yun, Muffat, Julien, Su, Kuan-Chung, Cohen, Malkiel A., Lungjangwa, Tenzin, Aubourg, Patrick, Cheeseman, Iain M., Jaenisch, Rudolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392048/
https://www.ncbi.nlm.nih.gov/pubmed/30304678
http://dx.doi.org/10.1016/j.celrep.2018.09.032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392048/
https://www.ncbi.nlm.nih.gov/pubmed/30304678
http://dx.doi.org/10.1016/j.celrep.2018.09.032

Ejemplares similares