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Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype
Most genes mutated in microcephaly patients are expressed ubiquitously, and yet the brain is the only major organ compromised in most patients. Why the phenotype remains brain specific is poorly understood. In this study, we used in vitro differentiation of human embryonic stem cells to monitor the...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392048/ https://www.ncbi.nlm.nih.gov/pubmed/30304678 http://dx.doi.org/10.1016/j.celrep.2018.09.032 |