Metabolic regulation of T cell development by Sin1–mTORC2 is mediated by pyruvate kinase M2

Glucose metabolism plays a key role in thymocyte development. The mammalian target of rapamycin complex 2 (mTORC2) is a critical regulator of cell growth and metabolism, but its role in early thymocyte development and metabolism has not been fully studied. We show here that genetic ablation of Sin1,...

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Detalles Bibliográficos
Autores principales: Ouyang, Xinxing, Han, Yuheng, Qu, Guojun, Li, Man, Wu, Ningbo, Liu, Hongzhi, Arojo, Omotooke, Sun, Hongxiang, Liu, Xiaobo, Liu, Dou, Chen, Lei, Zou, Qiang, Su, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392101/
https://www.ncbi.nlm.nih.gov/pubmed/30428057
http://dx.doi.org/10.1093/jmcb/mjy065

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