Cargando…

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs

Thiamine is an essential micronutrient that plays a key role in energy metabolism. Many populations worldwide may be at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on staple crops with low thiamine content, or food preparation practices, such as milling grains and...

Descripción completa

Detalles Bibliográficos
Autores principales: Whitfield, Kyly C., Bourassa, Megan W., Adamolekun, Bola, Bergeron, Gilles, Bettendorff, Lucien, Brown, Kenneth H., Cox, Lorna, Fattal‐Valevski, Aviva, Fischer, Philip R., Frank, Elizabeth L., Hiffler, Laurent, Hlaing, Lwin Mar, Jefferds, Maria Elena, Kapner, Hallie, Kounnavong, Sengchanh, Mousavi, Maral P.S., Roth, Daniel E., Tsaloglou, Maria‐Nefeli, Wieringa, Frank, Combs, Gerald F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392124/
https://www.ncbi.nlm.nih.gov/pubmed/30151974
http://dx.doi.org/10.1111/nyas.13919
Descripción
Sumario:Thiamine is an essential micronutrient that plays a key role in energy metabolism. Many populations worldwide may be at risk of clinical or subclinical thiamine deficiencies, due to famine, reliance on staple crops with low thiamine content, or food preparation practices, such as milling grains and washing milled rice. Clinical manifestations of thiamine deficiency are variable; this, along with the lack of a readily accessible and widely agreed upon biomarker of thiamine status, complicates efforts to diagnose thiamine deficiency and assess its global prevalence. Strategies to identify regions at risk of thiamine deficiency through proxy measures, such as analysis of food balance sheet data and month‐specific infant mortality rates, may be valuable for understanding the scope of thiamine deficiency. Urgent public health responses are warranted in high‐risk regions, considering the contribution of thiamine deficiency to infant mortality and research suggesting that even subclinical thiamine deficiency in childhood may have lifelong neurodevelopmental consequences. Food fortification and maternal and/or infant thiamine supplementation have proven effective in raising thiamine status and reducing the incidence of infantile beriberi in regions where thiamine deficiency is prevalent, but trial data are limited. Efforts to determine culturally and environmentally appropriate food vehicles for thiamine fortification are ongoing.