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Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo

Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide, and it particularly affects people living with human immunodeficiency virus (HIV). This study aimed to estimate the prevalence of HPV and to describe HPV genotypes in HIV-1 infected women in Lomé, Togo. F...

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Autores principales: Nyasenu, Yawo Tufa, Gbeasor-Komlanvi, Fifonsi Adjidossi, Ehlan, Amivi, Issa, Sabi Abdul-Raouf, Dossim, Sika, Kolou, Malewe, Yambiyo, Brice Martial, Prince-David, Mireille, Salou, Mounerou, Ekouevi, Didier Koumavi, Dagnra, Anoumou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392291/
https://www.ncbi.nlm.nih.gov/pubmed/30811454
http://dx.doi.org/10.1371/journal.pone.0212516
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author Nyasenu, Yawo Tufa
Gbeasor-Komlanvi, Fifonsi Adjidossi
Ehlan, Amivi
Issa, Sabi Abdul-Raouf
Dossim, Sika
Kolou, Malewe
Yambiyo, Brice Martial
Prince-David, Mireille
Salou, Mounerou
Ekouevi, Didier Koumavi
Dagnra, Anoumou
author_facet Nyasenu, Yawo Tufa
Gbeasor-Komlanvi, Fifonsi Adjidossi
Ehlan, Amivi
Issa, Sabi Abdul-Raouf
Dossim, Sika
Kolou, Malewe
Yambiyo, Brice Martial
Prince-David, Mireille
Salou, Mounerou
Ekouevi, Didier Koumavi
Dagnra, Anoumou
author_sort Nyasenu, Yawo Tufa
collection PubMed
description Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide, and it particularly affects people living with human immunodeficiency virus (HIV). This study aimed to estimate the prevalence of HPV and to describe HPV genotypes in HIV-1 infected women in Lomé, Togo. From September 2014 to September 2015, a cross-sectional study was conducted in two treatment and care centers for people living with HIV: the Centre Hospitalier Universitaire Sylvanus Olympio and the non-profit organization ‘Espoir Vie Togo’. Women living with HIV-1, aged 18 years and older, receiving a combination antiretroviral therapy for at least 12 months, and who gave their informed consent to participate in the study were recruited. Cervical swabs were collected using a cytobrush, and cells were stored in a preservative solution. HPV testing was performed using e-BRID equipment. Blood samples were collected for CD4+ count using a flow cytometer and for HIV viral load using polymerase chain reaction. A total of 221 HIV-1 infected women were enrolled. The prevalence of any type and oncogenic HPV was 22.2%, 95% confidence interval (95% CI): [17.1–28.2] and 16.7% (95%CI: 12.3–22.3), respectively. The most prevalent genotypes were: 18 (8.6%), 68 (4.1%), and 62/81 (2.7%). Only 1.3% (3/221) of participants were infected with HPV16. In regression analysis, no factor was associated with HRHPV. CONCLUSION: This study showed the diversity of circulating HPV genotypes in Togo. Programs of HPV vaccination and early detection of benign or precancerous lesions should be implemented to reduce cancer-related comorbidities.
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spelling pubmed-63922912019-03-08 Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo Nyasenu, Yawo Tufa Gbeasor-Komlanvi, Fifonsi Adjidossi Ehlan, Amivi Issa, Sabi Abdul-Raouf Dossim, Sika Kolou, Malewe Yambiyo, Brice Martial Prince-David, Mireille Salou, Mounerou Ekouevi, Didier Koumavi Dagnra, Anoumou PLoS One Research Article Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide, and it particularly affects people living with human immunodeficiency virus (HIV). This study aimed to estimate the prevalence of HPV and to describe HPV genotypes in HIV-1 infected women in Lomé, Togo. From September 2014 to September 2015, a cross-sectional study was conducted in two treatment and care centers for people living with HIV: the Centre Hospitalier Universitaire Sylvanus Olympio and the non-profit organization ‘Espoir Vie Togo’. Women living with HIV-1, aged 18 years and older, receiving a combination antiretroviral therapy for at least 12 months, and who gave their informed consent to participate in the study were recruited. Cervical swabs were collected using a cytobrush, and cells were stored in a preservative solution. HPV testing was performed using e-BRID equipment. Blood samples were collected for CD4+ count using a flow cytometer and for HIV viral load using polymerase chain reaction. A total of 221 HIV-1 infected women were enrolled. The prevalence of any type and oncogenic HPV was 22.2%, 95% confidence interval (95% CI): [17.1–28.2] and 16.7% (95%CI: 12.3–22.3), respectively. The most prevalent genotypes were: 18 (8.6%), 68 (4.1%), and 62/81 (2.7%). Only 1.3% (3/221) of participants were infected with HPV16. In regression analysis, no factor was associated with HRHPV. CONCLUSION: This study showed the diversity of circulating HPV genotypes in Togo. Programs of HPV vaccination and early detection of benign or precancerous lesions should be implemented to reduce cancer-related comorbidities. Public Library of Science 2019-02-27 /pmc/articles/PMC6392291/ /pubmed/30811454 http://dx.doi.org/10.1371/journal.pone.0212516 Text en © 2019 Nyasenu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nyasenu, Yawo Tufa
Gbeasor-Komlanvi, Fifonsi Adjidossi
Ehlan, Amivi
Issa, Sabi Abdul-Raouf
Dossim, Sika
Kolou, Malewe
Yambiyo, Brice Martial
Prince-David, Mireille
Salou, Mounerou
Ekouevi, Didier Koumavi
Dagnra, Anoumou
Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo
title Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo
title_full Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo
title_fullStr Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo
title_full_unstemmed Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo
title_short Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo
title_sort prevalence and distribution of human papillomavirus (hpv) genotypes among hiv infected women in lomé, togo
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392291/
https://www.ncbi.nlm.nih.gov/pubmed/30811454
http://dx.doi.org/10.1371/journal.pone.0212516
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