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Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo
Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide, and it particularly affects people living with human immunodeficiency virus (HIV). This study aimed to estimate the prevalence of HPV and to describe HPV genotypes in HIV-1 infected women in Lomé, Togo. F...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392291/ https://www.ncbi.nlm.nih.gov/pubmed/30811454 http://dx.doi.org/10.1371/journal.pone.0212516 |
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author | Nyasenu, Yawo Tufa Gbeasor-Komlanvi, Fifonsi Adjidossi Ehlan, Amivi Issa, Sabi Abdul-Raouf Dossim, Sika Kolou, Malewe Yambiyo, Brice Martial Prince-David, Mireille Salou, Mounerou Ekouevi, Didier Koumavi Dagnra, Anoumou |
author_facet | Nyasenu, Yawo Tufa Gbeasor-Komlanvi, Fifonsi Adjidossi Ehlan, Amivi Issa, Sabi Abdul-Raouf Dossim, Sika Kolou, Malewe Yambiyo, Brice Martial Prince-David, Mireille Salou, Mounerou Ekouevi, Didier Koumavi Dagnra, Anoumou |
author_sort | Nyasenu, Yawo Tufa |
collection | PubMed |
description | Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide, and it particularly affects people living with human immunodeficiency virus (HIV). This study aimed to estimate the prevalence of HPV and to describe HPV genotypes in HIV-1 infected women in Lomé, Togo. From September 2014 to September 2015, a cross-sectional study was conducted in two treatment and care centers for people living with HIV: the Centre Hospitalier Universitaire Sylvanus Olympio and the non-profit organization ‘Espoir Vie Togo’. Women living with HIV-1, aged 18 years and older, receiving a combination antiretroviral therapy for at least 12 months, and who gave their informed consent to participate in the study were recruited. Cervical swabs were collected using a cytobrush, and cells were stored in a preservative solution. HPV testing was performed using e-BRID equipment. Blood samples were collected for CD4+ count using a flow cytometer and for HIV viral load using polymerase chain reaction. A total of 221 HIV-1 infected women were enrolled. The prevalence of any type and oncogenic HPV was 22.2%, 95% confidence interval (95% CI): [17.1–28.2] and 16.7% (95%CI: 12.3–22.3), respectively. The most prevalent genotypes were: 18 (8.6%), 68 (4.1%), and 62/81 (2.7%). Only 1.3% (3/221) of participants were infected with HPV16. In regression analysis, no factor was associated with HRHPV. CONCLUSION: This study showed the diversity of circulating HPV genotypes in Togo. Programs of HPV vaccination and early detection of benign or precancerous lesions should be implemented to reduce cancer-related comorbidities. |
format | Online Article Text |
id | pubmed-6392291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63922912019-03-08 Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo Nyasenu, Yawo Tufa Gbeasor-Komlanvi, Fifonsi Adjidossi Ehlan, Amivi Issa, Sabi Abdul-Raouf Dossim, Sika Kolou, Malewe Yambiyo, Brice Martial Prince-David, Mireille Salou, Mounerou Ekouevi, Didier Koumavi Dagnra, Anoumou PLoS One Research Article Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide, and it particularly affects people living with human immunodeficiency virus (HIV). This study aimed to estimate the prevalence of HPV and to describe HPV genotypes in HIV-1 infected women in Lomé, Togo. From September 2014 to September 2015, a cross-sectional study was conducted in two treatment and care centers for people living with HIV: the Centre Hospitalier Universitaire Sylvanus Olympio and the non-profit organization ‘Espoir Vie Togo’. Women living with HIV-1, aged 18 years and older, receiving a combination antiretroviral therapy for at least 12 months, and who gave their informed consent to participate in the study were recruited. Cervical swabs were collected using a cytobrush, and cells were stored in a preservative solution. HPV testing was performed using e-BRID equipment. Blood samples were collected for CD4+ count using a flow cytometer and for HIV viral load using polymerase chain reaction. A total of 221 HIV-1 infected women were enrolled. The prevalence of any type and oncogenic HPV was 22.2%, 95% confidence interval (95% CI): [17.1–28.2] and 16.7% (95%CI: 12.3–22.3), respectively. The most prevalent genotypes were: 18 (8.6%), 68 (4.1%), and 62/81 (2.7%). Only 1.3% (3/221) of participants were infected with HPV16. In regression analysis, no factor was associated with HRHPV. CONCLUSION: This study showed the diversity of circulating HPV genotypes in Togo. Programs of HPV vaccination and early detection of benign or precancerous lesions should be implemented to reduce cancer-related comorbidities. Public Library of Science 2019-02-27 /pmc/articles/PMC6392291/ /pubmed/30811454 http://dx.doi.org/10.1371/journal.pone.0212516 Text en © 2019 Nyasenu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Nyasenu, Yawo Tufa Gbeasor-Komlanvi, Fifonsi Adjidossi Ehlan, Amivi Issa, Sabi Abdul-Raouf Dossim, Sika Kolou, Malewe Yambiyo, Brice Martial Prince-David, Mireille Salou, Mounerou Ekouevi, Didier Koumavi Dagnra, Anoumou Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo |
title | Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo |
title_full | Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo |
title_fullStr | Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo |
title_full_unstemmed | Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo |
title_short | Prevalence and distribution of Human Papillomavirus (HPV) genotypes among HIV infected women in Lomé, Togo |
title_sort | prevalence and distribution of human papillomavirus (hpv) genotypes among hiv infected women in lomé, togo |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392291/ https://www.ncbi.nlm.nih.gov/pubmed/30811454 http://dx.doi.org/10.1371/journal.pone.0212516 |
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