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Tranexamic acid reduces blood loss in intertrochanteric fractures: A meta-analysis from randomized controlled trials

BACKGROUND: This meta-analysis aims to assess the efficacy and safety of tranexamic acid for reducing blood loss and transfusion requirements in patients with intertrochanteric fractures. METHODS: We conduct electronic searches of Medline (1966–2017.09), PubMed (1966–2017.09), Embase (1980–2017.09),...

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Autores principales: Wang, Weidong, Yu, Jincong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392608/
https://www.ncbi.nlm.nih.gov/pubmed/29384916
http://dx.doi.org/10.1097/MD.0000000000009396
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author Wang, Weidong
Yu, Jincong
author_facet Wang, Weidong
Yu, Jincong
author_sort Wang, Weidong
collection PubMed
description BACKGROUND: This meta-analysis aims to assess the efficacy and safety of tranexamic acid for reducing blood loss and transfusion requirements in patients with intertrochanteric fractures. METHODS: We conduct electronic searches of Medline (1966–2017.09), PubMed (1966–2017.09), Embase (1980–2017.09), ScienceDirect (1985–2017.09), and the Cochrane Library. Only randomized controlled trials (RCTs) are included. The quality assessments are performed according to the Cochrane systematic review method. Fixed/random-effect model is used according to the heterogeneity tested by I(2) statistic. Meta-analysis is performed using Stata 11.0 software. RESULTS: A total of 4 RCTs are retrieved involving 514 participants. The present meta-analysis indicated that there were significant differences between groups in terms of total blood loss (weighted mean differences = −131.49, 95% confidence interval (CI): −163.63 to −99.35, P = .00), hemoglobin decline (weighted mean differences = −0.31, 95% CI, −0.44 to −0.19, P = .00), and transfusion rate (risk differences = −1.11, 95% CI, −0.19 to −0.04, P = .00). In addition, no increased risk of adverse effects was identified in both groups. CONCLUSION: Local administration of tranexamic acid is associated with a reduced total blood loss, postoperative hemoglobin decline, and transfusion requirements in patients with intertrochanteric fractures. High-quality RCTs are still required for further investigation.
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spelling pubmed-63926082019-03-15 Tranexamic acid reduces blood loss in intertrochanteric fractures: A meta-analysis from randomized controlled trials Wang, Weidong Yu, Jincong Medicine (Baltimore) Research Article BACKGROUND: This meta-analysis aims to assess the efficacy and safety of tranexamic acid for reducing blood loss and transfusion requirements in patients with intertrochanteric fractures. METHODS: We conduct electronic searches of Medline (1966–2017.09), PubMed (1966–2017.09), Embase (1980–2017.09), ScienceDirect (1985–2017.09), and the Cochrane Library. Only randomized controlled trials (RCTs) are included. The quality assessments are performed according to the Cochrane systematic review method. Fixed/random-effect model is used according to the heterogeneity tested by I(2) statistic. Meta-analysis is performed using Stata 11.0 software. RESULTS: A total of 4 RCTs are retrieved involving 514 participants. The present meta-analysis indicated that there were significant differences between groups in terms of total blood loss (weighted mean differences = −131.49, 95% confidence interval (CI): −163.63 to −99.35, P = .00), hemoglobin decline (weighted mean differences = −0.31, 95% CI, −0.44 to −0.19, P = .00), and transfusion rate (risk differences = −1.11, 95% CI, −0.19 to −0.04, P = .00). In addition, no increased risk of adverse effects was identified in both groups. CONCLUSION: Local administration of tranexamic acid is associated with a reduced total blood loss, postoperative hemoglobin decline, and transfusion requirements in patients with intertrochanteric fractures. High-quality RCTs are still required for further investigation. Wolters Kluwer Health 2017-12-29 /pmc/articles/PMC6392608/ /pubmed/29384916 http://dx.doi.org/10.1097/MD.0000000000009396 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Research Article
Wang, Weidong
Yu, Jincong
Tranexamic acid reduces blood loss in intertrochanteric fractures: A meta-analysis from randomized controlled trials
title Tranexamic acid reduces blood loss in intertrochanteric fractures: A meta-analysis from randomized controlled trials
title_full Tranexamic acid reduces blood loss in intertrochanteric fractures: A meta-analysis from randomized controlled trials
title_fullStr Tranexamic acid reduces blood loss in intertrochanteric fractures: A meta-analysis from randomized controlled trials
title_full_unstemmed Tranexamic acid reduces blood loss in intertrochanteric fractures: A meta-analysis from randomized controlled trials
title_short Tranexamic acid reduces blood loss in intertrochanteric fractures: A meta-analysis from randomized controlled trials
title_sort tranexamic acid reduces blood loss in intertrochanteric fractures: a meta-analysis from randomized controlled trials
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392608/
https://www.ncbi.nlm.nih.gov/pubmed/29384916
http://dx.doi.org/10.1097/MD.0000000000009396
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