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Correlations between clinical features and death in patients with severe fever with thrombocytopenia syndrome
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging high-fatality infectious disease caused by a novel phlebovirus belonging to the Bunyaviridae family. Thus, the independent predictors of death in this disease must be identified to improve the survival of affected patients. A total of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392624/ https://www.ncbi.nlm.nih.gov/pubmed/29851797 http://dx.doi.org/10.1097/MD.0000000000010848 |
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author | Hu, Jianhua Li, Siying Zhang, Xuan Zhao, Hong Yang, Meifang Xu, Lichen Li, Lanjuan |
author_facet | Hu, Jianhua Li, Siying Zhang, Xuan Zhao, Hong Yang, Meifang Xu, Lichen Li, Lanjuan |
author_sort | Hu, Jianhua |
collection | PubMed |
description | Severe fever with thrombocytopenia syndrome (SFTS) is an emerging high-fatality infectious disease caused by a novel phlebovirus belonging to the Bunyaviridae family. Thus, the independent predictors of death in this disease must be identified to improve the survival of affected patients. A total of 25 hospitalized patients with SFTS virus infection were enrolled in our study, and their medical records and laboratory data were reviewed. The risk factors for death were examined by binary logistic regression. The patient age was significantly higher in the deceased cases than in those who recovered (P = .020). Moreover, the occurrence of shock, respiratory failure, hemorrhagic manifestations, kidney dysfunction, and arrhythmia was significantly more common in the deceased cases than in the recovered cases (P = .016, P = .004, P = .005, P = .002, P = .038). Univariate binary logistic regression showed that shock, arrhythmia, and hemorrhage, as well as PCT, serum creatinine (Scr), and blood urea nitrogen (BUN) elevations, were the risk factors for death (odds ratio, OR 28.5, P = .015; OR 13.5, P = .027; OR 36, P = .008; OR 28.5, P = .015; OR 36, P = .008; and OR 76.0, P = .004). However, the BUN increase was the only independent risk factor for death indicated by multivariate logistic regression (OR 76.0, P = .004). SFTS presents with a high fatality rate. When patients with SFTS manifest shock, arrhythmia, hemorrhage, PCT increase, and Scr and BUN elevations, especially BUN > 8.2 μmol/L, health care providers should be alerted and must administer early intervention to prevent the progress to death. |
format | Online Article Text |
id | pubmed-6392624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-63926242019-03-15 Correlations between clinical features and death in patients with severe fever with thrombocytopenia syndrome Hu, Jianhua Li, Siying Zhang, Xuan Zhao, Hong Yang, Meifang Xu, Lichen Li, Lanjuan Medicine (Baltimore) Research Article Severe fever with thrombocytopenia syndrome (SFTS) is an emerging high-fatality infectious disease caused by a novel phlebovirus belonging to the Bunyaviridae family. Thus, the independent predictors of death in this disease must be identified to improve the survival of affected patients. A total of 25 hospitalized patients with SFTS virus infection were enrolled in our study, and their medical records and laboratory data were reviewed. The risk factors for death were examined by binary logistic regression. The patient age was significantly higher in the deceased cases than in those who recovered (P = .020). Moreover, the occurrence of shock, respiratory failure, hemorrhagic manifestations, kidney dysfunction, and arrhythmia was significantly more common in the deceased cases than in the recovered cases (P = .016, P = .004, P = .005, P = .002, P = .038). Univariate binary logistic regression showed that shock, arrhythmia, and hemorrhage, as well as PCT, serum creatinine (Scr), and blood urea nitrogen (BUN) elevations, were the risk factors for death (odds ratio, OR 28.5, P = .015; OR 13.5, P = .027; OR 36, P = .008; OR 28.5, P = .015; OR 36, P = .008; and OR 76.0, P = .004). However, the BUN increase was the only independent risk factor for death indicated by multivariate logistic regression (OR 76.0, P = .004). SFTS presents with a high fatality rate. When patients with SFTS manifest shock, arrhythmia, hemorrhage, PCT increase, and Scr and BUN elevations, especially BUN > 8.2 μmol/L, health care providers should be alerted and must administer early intervention to prevent the progress to death. Wolters Kluwer Health 2018-06-01 /pmc/articles/PMC6392624/ /pubmed/29851797 http://dx.doi.org/10.1097/MD.0000000000010848 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | Research Article Hu, Jianhua Li, Siying Zhang, Xuan Zhao, Hong Yang, Meifang Xu, Lichen Li, Lanjuan Correlations between clinical features and death in patients with severe fever with thrombocytopenia syndrome |
title | Correlations between clinical features and death in patients with severe fever with thrombocytopenia syndrome |
title_full | Correlations between clinical features and death in patients with severe fever with thrombocytopenia syndrome |
title_fullStr | Correlations between clinical features and death in patients with severe fever with thrombocytopenia syndrome |
title_full_unstemmed | Correlations between clinical features and death in patients with severe fever with thrombocytopenia syndrome |
title_short | Correlations between clinical features and death in patients with severe fever with thrombocytopenia syndrome |
title_sort | correlations between clinical features and death in patients with severe fever with thrombocytopenia syndrome |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392624/ https://www.ncbi.nlm.nih.gov/pubmed/29851797 http://dx.doi.org/10.1097/MD.0000000000010848 |
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