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Usefulness of F-18 FP-CIT PET to predict dopamine-responsive hand tremor in patients other than Parkinson's disease: Two case reports

RATIONALE: Treating the patients with hand tremors is clinically difficult, because a wide range of disorders can result in hand tremors. Therefore, when treatment for hand tremors begins, various pharmacological options have to be considered. In clinical practice, a practical approach is to initial...

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Autores principales: Yu, Kwang Jae, Lee, Byung Joo, Han, Jin, Park, Donghwi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392691/
https://www.ncbi.nlm.nih.gov/pubmed/29851853
http://dx.doi.org/10.1097/MD.0000000000010983
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author Yu, Kwang Jae
Lee, Byung Joo
Han, Jin
Park, Donghwi
author_facet Yu, Kwang Jae
Lee, Byung Joo
Han, Jin
Park, Donghwi
author_sort Yu, Kwang Jae
collection PubMed
description RATIONALE: Treating the patients with hand tremors is clinically difficult, because a wide range of disorders can result in hand tremors. Therefore, when treatment for hand tremors begins, various pharmacological options have to be considered. In clinical practice, a practical approach is to initially check hand tremor patients for signs of Parkinson's disease (PD), because patients with PD can benefit from dopamine treatment. However, only part of patients with PD tends to show a meaningful improvement in hand tremors for dopamine treatment. On the other hand, dopamine treatment may help with hand tremors of patients with other disorders, but dopamine responsiveness can‘t be predicted by clinical assessment alone. PATIENTS CONCERNS: Hand tremors. DIAGNOSES: Hemiplegic patients (A 78-year-old man with cerebral infarction and a 65-year-old woman with traumatic brain injury) with hemi-sided hand tremor. INTERVENTIONS: Fluorinated N-3-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (F-18 FP-CIT) positron emission tomography (PET) and dopamine agonist. OUTCOMES: After the medication, hemi-side hand tremor dramatically improved. LESSONS: Collectively, a dysfunction of the dopaminergic nigro-striatal pathway may lead to abnormal findings of F-18 FP-CIT PET, and these abnormal findings in brain-lesion patients with hand tremor may help predict dopamine responsiveness of hand tremor. We believe that our report may be helpful in the diagnosis and treatment of hand tremor in patients with brain-lesion.
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spelling pubmed-63926912019-03-15 Usefulness of F-18 FP-CIT PET to predict dopamine-responsive hand tremor in patients other than Parkinson's disease: Two case reports Yu, Kwang Jae Lee, Byung Joo Han, Jin Park, Donghwi Medicine (Baltimore) Research Article RATIONALE: Treating the patients with hand tremors is clinically difficult, because a wide range of disorders can result in hand tremors. Therefore, when treatment for hand tremors begins, various pharmacological options have to be considered. In clinical practice, a practical approach is to initially check hand tremor patients for signs of Parkinson's disease (PD), because patients with PD can benefit from dopamine treatment. However, only part of patients with PD tends to show a meaningful improvement in hand tremors for dopamine treatment. On the other hand, dopamine treatment may help with hand tremors of patients with other disorders, but dopamine responsiveness can‘t be predicted by clinical assessment alone. PATIENTS CONCERNS: Hand tremors. DIAGNOSES: Hemiplegic patients (A 78-year-old man with cerebral infarction and a 65-year-old woman with traumatic brain injury) with hemi-sided hand tremor. INTERVENTIONS: Fluorinated N-3-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (F-18 FP-CIT) positron emission tomography (PET) and dopamine agonist. OUTCOMES: After the medication, hemi-side hand tremor dramatically improved. LESSONS: Collectively, a dysfunction of the dopaminergic nigro-striatal pathway may lead to abnormal findings of F-18 FP-CIT PET, and these abnormal findings in brain-lesion patients with hand tremor may help predict dopamine responsiveness of hand tremor. We believe that our report may be helpful in the diagnosis and treatment of hand tremor in patients with brain-lesion. Wolters Kluwer Health 2018-06-01 /pmc/articles/PMC6392691/ /pubmed/29851853 http://dx.doi.org/10.1097/MD.0000000000010983 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Yu, Kwang Jae
Lee, Byung Joo
Han, Jin
Park, Donghwi
Usefulness of F-18 FP-CIT PET to predict dopamine-responsive hand tremor in patients other than Parkinson's disease: Two case reports
title Usefulness of F-18 FP-CIT PET to predict dopamine-responsive hand tremor in patients other than Parkinson's disease: Two case reports
title_full Usefulness of F-18 FP-CIT PET to predict dopamine-responsive hand tremor in patients other than Parkinson's disease: Two case reports
title_fullStr Usefulness of F-18 FP-CIT PET to predict dopamine-responsive hand tremor in patients other than Parkinson's disease: Two case reports
title_full_unstemmed Usefulness of F-18 FP-CIT PET to predict dopamine-responsive hand tremor in patients other than Parkinson's disease: Two case reports
title_short Usefulness of F-18 FP-CIT PET to predict dopamine-responsive hand tremor in patients other than Parkinson's disease: Two case reports
title_sort usefulness of f-18 fp-cit pet to predict dopamine-responsive hand tremor in patients other than parkinson's disease: two case reports
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392691/
https://www.ncbi.nlm.nih.gov/pubmed/29851853
http://dx.doi.org/10.1097/MD.0000000000010983
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