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MMP-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in Chinese Han population

Ankylosing spondylitis (AS) is an extreme form of inflammatory arthritis which always leads to bony fusion of vertebral and chronic pain of back. A lot of genes including interleukin, matrix metalloproteinases (MMPs), and endoplasmic reticulum aminopeptidase were found associated with AS. MMP family...

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Autores principales: Meng, Chenyang, Bai, Rui, Zhao, Zhenqun, Huang, Guimei, Jin, Tianbo, Feng, Wei, Liu, Wanlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392754/
https://www.ncbi.nlm.nih.gov/pubmed/30170451
http://dx.doi.org/10.1097/MD.0000000000012136
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author Meng, Chenyang
Bai, Rui
Zhao, Zhenqun
Huang, Guimei
Jin, Tianbo
Feng, Wei
Liu, Wanlin
author_facet Meng, Chenyang
Bai, Rui
Zhao, Zhenqun
Huang, Guimei
Jin, Tianbo
Feng, Wei
Liu, Wanlin
author_sort Meng, Chenyang
collection PubMed
description Ankylosing spondylitis (AS) is an extreme form of inflammatory arthritis which always leads to bony fusion of vertebral and chronic pain of back. A lot of genes including interleukin, matrix metalloproteinases (MMPs), and endoplasmic reticulum aminopeptidase were found associated with AS. MMP family members were involved in the autoimmune disease and orthopedic diseases such as rheumatoid arthritis and osteoarthritis, while few studies concentrated on the correlation between single-nucleotide polymorphisms (SNPs) in MMP and AS. In addition, there is no report on the relationship between MMP-8 and AS. To investigate the association between SNPs in MMP-8 and AS, we recruited 268 patients with AS and 654 healthy people to conduct a case–control study. Five SNPs including rs3740938, rs2012390, rs1940475, rs11225394, and rs11225395 of MMP-8 gene were genotyped. It was found rs3740938 of MMP-8 was associated with an increased risk of AS under the dominant model and additive model after adjustment for gender and age by performing logistic regression analysis (odds ratio [OR] = 1.49, 95% confidence interval [CI] = 1.02–2.18, P = .038; OR = 1.37, 95% CI = 1.01–1.87, P = .042, respectively). Moreover, haplotype “GGTCA” was associated with an increased risk of AS without adjustment for age and gender (OR = 1.75, 95% CI = 1.05–2.92, P = .032), while no positive result was found after adjustment for age and gender. Based on our results, our study indicates significant association between SNPs of MMP-8 and AS risk in a Chinese Han population and these results provide the first evidence that MMP-8 is correlated with AS.
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spelling pubmed-63927542019-03-15 MMP-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in Chinese Han population Meng, Chenyang Bai, Rui Zhao, Zhenqun Huang, Guimei Jin, Tianbo Feng, Wei Liu, Wanlin Medicine (Baltimore) Research Article Ankylosing spondylitis (AS) is an extreme form of inflammatory arthritis which always leads to bony fusion of vertebral and chronic pain of back. A lot of genes including interleukin, matrix metalloproteinases (MMPs), and endoplasmic reticulum aminopeptidase were found associated with AS. MMP family members were involved in the autoimmune disease and orthopedic diseases such as rheumatoid arthritis and osteoarthritis, while few studies concentrated on the correlation between single-nucleotide polymorphisms (SNPs) in MMP and AS. In addition, there is no report on the relationship between MMP-8 and AS. To investigate the association between SNPs in MMP-8 and AS, we recruited 268 patients with AS and 654 healthy people to conduct a case–control study. Five SNPs including rs3740938, rs2012390, rs1940475, rs11225394, and rs11225395 of MMP-8 gene were genotyped. It was found rs3740938 of MMP-8 was associated with an increased risk of AS under the dominant model and additive model after adjustment for gender and age by performing logistic regression analysis (odds ratio [OR] = 1.49, 95% confidence interval [CI] = 1.02–2.18, P = .038; OR = 1.37, 95% CI = 1.01–1.87, P = .042, respectively). Moreover, haplotype “GGTCA” was associated with an increased risk of AS without adjustment for age and gender (OR = 1.75, 95% CI = 1.05–2.92, P = .032), while no positive result was found after adjustment for age and gender. Based on our results, our study indicates significant association between SNPs of MMP-8 and AS risk in a Chinese Han population and these results provide the first evidence that MMP-8 is correlated with AS. Wolters Kluwer Health 2018-08-21 /pmc/articles/PMC6392754/ /pubmed/30170451 http://dx.doi.org/10.1097/MD.0000000000012136 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Article
Meng, Chenyang
Bai, Rui
Zhao, Zhenqun
Huang, Guimei
Jin, Tianbo
Feng, Wei
Liu, Wanlin
MMP-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in Chinese Han population
title MMP-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in Chinese Han population
title_full MMP-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in Chinese Han population
title_fullStr MMP-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in Chinese Han population
title_full_unstemmed MMP-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in Chinese Han population
title_short MMP-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in Chinese Han population
title_sort mmp-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in chinese han population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392754/
https://www.ncbi.nlm.nih.gov/pubmed/30170451
http://dx.doi.org/10.1097/MD.0000000000012136
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