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Down-regulated of PCDH10 predicts poor prognosis in hepatocellular carcinoma patients

Protocadherin10 (PCDH10), a member of the nonclustered protocadherin family, functions as a tumor suppressor in many cancers. The aim of this study was to evaluate the expression level and prognostic value of PCDH10 in hepatocellular carcinoma (HCC) patients. Quantitative real-time polymerase chain...

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Autores principales: Bing, Yuntao, Tian, Maolin, Li, Gang, Jiang, Bin, Ma, Zhaolai, Li, Lei, Wang, Liang, Wang, Hangyan, Xiu, Dianrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392931/
https://www.ncbi.nlm.nih.gov/pubmed/30170418
http://dx.doi.org/10.1097/MD.0000000000012055
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author Bing, Yuntao
Tian, Maolin
Li, Gang
Jiang, Bin
Ma, Zhaolai
Li, Lei
Wang, Liang
Wang, Hangyan
Xiu, Dianrong
author_facet Bing, Yuntao
Tian, Maolin
Li, Gang
Jiang, Bin
Ma, Zhaolai
Li, Lei
Wang, Liang
Wang, Hangyan
Xiu, Dianrong
author_sort Bing, Yuntao
collection PubMed
description Protocadherin10 (PCDH10), a member of the nonclustered protocadherin family, functions as a tumor suppressor in many cancers. The aim of this study was to evaluate the expression level and prognostic value of PCDH10 in hepatocellular carcinoma (HCC) patients. Quantitative real-time polymerase chain reaction was used to analyze the expression level of PCDH10 in HCC tissues and adjacent nontumor tissues. The association of PCDH10 expression with clinicopathological features of patients was evaluated by chi-squared test. Overall survival was estimated using the Kaplan–Meier method. Besides, the patient prognosis was also evaluated by Cox regression analysis. PCDH10 expression was significantly lower in HCC tissues than that in adjacent nontumor tissues (P = .000). Kaplan–Meier curves showed that patients with lower PCDH10 expression had a worse overall survival. Moreover, PCDH10 expression level was associated tumor size (P = .005), tumor node metastasis stage (P = .002), smoking status (P = .000), and drinking status (P = .005). Multivariate analysis showed that the expression of PCDH10 (P = .000; hazard ratio = 4.784; 95% confidence interval: 2.550–8.977) was an independently associated with poor overall survival rates, as well as smoking status and drinking status. Our findings indicated that the decreased expression of PCDH10 was closely associated with poor prognosis of HCC patients. It might be considered as a valuable biomarker for HCC.
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spelling pubmed-63929312019-03-15 Down-regulated of PCDH10 predicts poor prognosis in hepatocellular carcinoma patients Bing, Yuntao Tian, Maolin Li, Gang Jiang, Bin Ma, Zhaolai Li, Lei Wang, Liang Wang, Hangyan Xiu, Dianrong Medicine (Baltimore) Research Article Protocadherin10 (PCDH10), a member of the nonclustered protocadherin family, functions as a tumor suppressor in many cancers. The aim of this study was to evaluate the expression level and prognostic value of PCDH10 in hepatocellular carcinoma (HCC) patients. Quantitative real-time polymerase chain reaction was used to analyze the expression level of PCDH10 in HCC tissues and adjacent nontumor tissues. The association of PCDH10 expression with clinicopathological features of patients was evaluated by chi-squared test. Overall survival was estimated using the Kaplan–Meier method. Besides, the patient prognosis was also evaluated by Cox regression analysis. PCDH10 expression was significantly lower in HCC tissues than that in adjacent nontumor tissues (P = .000). Kaplan–Meier curves showed that patients with lower PCDH10 expression had a worse overall survival. Moreover, PCDH10 expression level was associated tumor size (P = .005), tumor node metastasis stage (P = .002), smoking status (P = .000), and drinking status (P = .005). Multivariate analysis showed that the expression of PCDH10 (P = .000; hazard ratio = 4.784; 95% confidence interval: 2.550–8.977) was an independently associated with poor overall survival rates, as well as smoking status and drinking status. Our findings indicated that the decreased expression of PCDH10 was closely associated with poor prognosis of HCC patients. It might be considered as a valuable biomarker for HCC. Wolters Kluwer Health 2018-08-21 /pmc/articles/PMC6392931/ /pubmed/30170418 http://dx.doi.org/10.1097/MD.0000000000012055 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle Research Article
Bing, Yuntao
Tian, Maolin
Li, Gang
Jiang, Bin
Ma, Zhaolai
Li, Lei
Wang, Liang
Wang, Hangyan
Xiu, Dianrong
Down-regulated of PCDH10 predicts poor prognosis in hepatocellular carcinoma patients
title Down-regulated of PCDH10 predicts poor prognosis in hepatocellular carcinoma patients
title_full Down-regulated of PCDH10 predicts poor prognosis in hepatocellular carcinoma patients
title_fullStr Down-regulated of PCDH10 predicts poor prognosis in hepatocellular carcinoma patients
title_full_unstemmed Down-regulated of PCDH10 predicts poor prognosis in hepatocellular carcinoma patients
title_short Down-regulated of PCDH10 predicts poor prognosis in hepatocellular carcinoma patients
title_sort down-regulated of pcdh10 predicts poor prognosis in hepatocellular carcinoma patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392931/
https://www.ncbi.nlm.nih.gov/pubmed/30170418
http://dx.doi.org/10.1097/MD.0000000000012055
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