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Upregulation of transmembrane 4 L6 family member 1 predicts poor prognosis in invasive breast cancer: A STROBE-compliant article
Transmembrane 4 L6 family member 1 (TM4SF1) belongs to the 4-transmembrane-domain family and functions as an oncogene in multiple human cancers. In this work, we aim to determine TM4SF1 expression and its prognostic impact on patients with invasive breast cancer. Overall, we enrolled 209 invasive br...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392956/ https://www.ncbi.nlm.nih.gov/pubmed/29384939 http://dx.doi.org/10.1097/MD.0000000000009476 |
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author | Xing, Peng Dong, Huiting Liu, Qun Zhao, Tingting Yao, Fan Xu, Yingying Chen, Bo Zheng, Xinyu Wu, Yunfei Jin, Feng Li, Jiguang |
author_facet | Xing, Peng Dong, Huiting Liu, Qun Zhao, Tingting Yao, Fan Xu, Yingying Chen, Bo Zheng, Xinyu Wu, Yunfei Jin, Feng Li, Jiguang |
author_sort | Xing, Peng |
collection | PubMed |
description | Transmembrane 4 L6 family member 1 (TM4SF1) belongs to the 4-transmembrane-domain family and functions as an oncogene in multiple human cancers. In this work, we aim to determine TM4SF1 expression and its prognostic impact on patients with invasive breast cancer. Overall, we enrolled 209 invasive breast cancer patients and immunohistochemically examined the expression of TM4SF1 in tumor specimens. The relationship between TM4SF1 expression and clinicopathological parameter and patient survival of breast cancer patients was analyzed. Among the 209 cases, 137 (65.6%) exhibited high expression of TM4SF1. High TM4SF1 expression was significantly associated with advanced histological grade and negative estrogen receptor and progesterone receptor status. Triple-negative breast cancer (TNBC) tumors were more likely to express high levels of TM4SF1 than non-TNBC cases. Patients with high tumoral expression of TM4SF1 had a significantly shorter disease-free survival (DFS; P = .00) and overall survival (OS; P = .01) than those with low expression of TM4SF1. When survival analysis was restricted to the 167 patients (79.9%) receiving adjuvant chemotherapy, TM4SF1 expression was also correlated with poorer DFS and OS (P = .00). In multiple Cox regression analysis TM4SF1 expression remained an independent prognostic indicator for OS and DFS. TM4SF1 is upregulated and serves as an independent poor prognostic indicator in invasive breast cancer. |
format | Online Article Text |
id | pubmed-6392956 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-63929562019-03-15 Upregulation of transmembrane 4 L6 family member 1 predicts poor prognosis in invasive breast cancer: A STROBE-compliant article Xing, Peng Dong, Huiting Liu, Qun Zhao, Tingting Yao, Fan Xu, Yingying Chen, Bo Zheng, Xinyu Wu, Yunfei Jin, Feng Li, Jiguang Medicine (Baltimore) Research Article Transmembrane 4 L6 family member 1 (TM4SF1) belongs to the 4-transmembrane-domain family and functions as an oncogene in multiple human cancers. In this work, we aim to determine TM4SF1 expression and its prognostic impact on patients with invasive breast cancer. Overall, we enrolled 209 invasive breast cancer patients and immunohistochemically examined the expression of TM4SF1 in tumor specimens. The relationship between TM4SF1 expression and clinicopathological parameter and patient survival of breast cancer patients was analyzed. Among the 209 cases, 137 (65.6%) exhibited high expression of TM4SF1. High TM4SF1 expression was significantly associated with advanced histological grade and negative estrogen receptor and progesterone receptor status. Triple-negative breast cancer (TNBC) tumors were more likely to express high levels of TM4SF1 than non-TNBC cases. Patients with high tumoral expression of TM4SF1 had a significantly shorter disease-free survival (DFS; P = .00) and overall survival (OS; P = .01) than those with low expression of TM4SF1. When survival analysis was restricted to the 167 patients (79.9%) receiving adjuvant chemotherapy, TM4SF1 expression was also correlated with poorer DFS and OS (P = .00). In multiple Cox regression analysis TM4SF1 expression remained an independent prognostic indicator for OS and DFS. TM4SF1 is upregulated and serves as an independent poor prognostic indicator in invasive breast cancer. Wolters Kluwer Health 2017-12-29 /pmc/articles/PMC6392956/ /pubmed/29384939 http://dx.doi.org/10.1097/MD.0000000000009476 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Xing, Peng Dong, Huiting Liu, Qun Zhao, Tingting Yao, Fan Xu, Yingying Chen, Bo Zheng, Xinyu Wu, Yunfei Jin, Feng Li, Jiguang Upregulation of transmembrane 4 L6 family member 1 predicts poor prognosis in invasive breast cancer: A STROBE-compliant article |
title | Upregulation of transmembrane 4 L6 family member 1 predicts poor prognosis in invasive breast cancer: A STROBE-compliant article |
title_full | Upregulation of transmembrane 4 L6 family member 1 predicts poor prognosis in invasive breast cancer: A STROBE-compliant article |
title_fullStr | Upregulation of transmembrane 4 L6 family member 1 predicts poor prognosis in invasive breast cancer: A STROBE-compliant article |
title_full_unstemmed | Upregulation of transmembrane 4 L6 family member 1 predicts poor prognosis in invasive breast cancer: A STROBE-compliant article |
title_short | Upregulation of transmembrane 4 L6 family member 1 predicts poor prognosis in invasive breast cancer: A STROBE-compliant article |
title_sort | upregulation of transmembrane 4 l6 family member 1 predicts poor prognosis in invasive breast cancer: a strobe-compliant article |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392956/ https://www.ncbi.nlm.nih.gov/pubmed/29384939 http://dx.doi.org/10.1097/MD.0000000000009476 |
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