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Standard versus extralevator abdominoperineal excision and oncologic outcomes for patients with distal rectal cancer: A meta-analysis
BACKGROUND: The role of extralevator abdominoperineal excision (ELAPE) for distal rectal cancer remains controversial, and the procedure is not widely accepted or practiced. METHODS: An electronic search of Medline, EMBASE, Web of Science, and similar databases for articles in English was performed...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393134/ https://www.ncbi.nlm.nih.gov/pubmed/29384902 http://dx.doi.org/10.1097/MD.0000000000009150 |
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author | Zhang, Yunfeng Wang, Duo Zhu, Lizhe Wang, Bin Ma, Xiaoxia Shi, Bohui Yan, Yu Zhou, Can |
author_facet | Zhang, Yunfeng Wang, Duo Zhu, Lizhe Wang, Bin Ma, Xiaoxia Shi, Bohui Yan, Yu Zhou, Can |
author_sort | Zhang, Yunfeng |
collection | PubMed |
description | BACKGROUND: The role of extralevator abdominoperineal excision (ELAPE) for distal rectal cancer remains controversial, and the procedure is not widely accepted or practiced. METHODS: An electronic search of Medline, EMBASE, Web of Science, and similar databases for articles in English was performed from the inception of the study until October 31, 2017. Two reviewers extracted information and independently assessed the quality of included studies by the methodological index for nonrandomized studies, then data were analyzed with Review Manager 5.3 software and Stata version 12.0 software. RESULTS: Our meta-analysis included 17 studies with 3479 patients, of whom 1915 (55.0%) underwent ELAPE and 1564 (44.0%) underwent abdominoperineal excision (APE). Compared with patients undergoing APE, patients undergoing ELAPE had a significant reduced risk of no more than 3 years local recurrence (LR) (risk ratio [RR] = 0.27, 95% confidence interval [CI] = 0.08–0.94), 3-year mortality (odds ratio [OR] = 0.45, 95% CI = 0.20–0.97), intraoperative bowel perforation (IBP) involvement (RR = 0.48, 95% CI = 0.31–0.74), and circumferential resection margin (CRM) positivity (RR = 0.66, 95% CI = 0.43–1.00) at the threshold level. CONCLUSIONS: The application of ELAPE is more effective in reducing the chance of 3 years LR, mortality, IBP involvement and CRM positivity than conventional APE, and worthy of being widely applied in surgical treatment of the distal rectal cancer. |
format | Online Article Text |
id | pubmed-6393134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-63931342019-03-15 Standard versus extralevator abdominoperineal excision and oncologic outcomes for patients with distal rectal cancer: A meta-analysis Zhang, Yunfeng Wang, Duo Zhu, Lizhe Wang, Bin Ma, Xiaoxia Shi, Bohui Yan, Yu Zhou, Can Medicine (Baltimore) Research Article BACKGROUND: The role of extralevator abdominoperineal excision (ELAPE) for distal rectal cancer remains controversial, and the procedure is not widely accepted or practiced. METHODS: An electronic search of Medline, EMBASE, Web of Science, and similar databases for articles in English was performed from the inception of the study until October 31, 2017. Two reviewers extracted information and independently assessed the quality of included studies by the methodological index for nonrandomized studies, then data were analyzed with Review Manager 5.3 software and Stata version 12.0 software. RESULTS: Our meta-analysis included 17 studies with 3479 patients, of whom 1915 (55.0%) underwent ELAPE and 1564 (44.0%) underwent abdominoperineal excision (APE). Compared with patients undergoing APE, patients undergoing ELAPE had a significant reduced risk of no more than 3 years local recurrence (LR) (risk ratio [RR] = 0.27, 95% confidence interval [CI] = 0.08–0.94), 3-year mortality (odds ratio [OR] = 0.45, 95% CI = 0.20–0.97), intraoperative bowel perforation (IBP) involvement (RR = 0.48, 95% CI = 0.31–0.74), and circumferential resection margin (CRM) positivity (RR = 0.66, 95% CI = 0.43–1.00) at the threshold level. CONCLUSIONS: The application of ELAPE is more effective in reducing the chance of 3 years LR, mortality, IBP involvement and CRM positivity than conventional APE, and worthy of being widely applied in surgical treatment of the distal rectal cancer. Wolters Kluwer Health 2017-12-29 /pmc/articles/PMC6393134/ /pubmed/29384902 http://dx.doi.org/10.1097/MD.0000000000009150 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | Research Article Zhang, Yunfeng Wang, Duo Zhu, Lizhe Wang, Bin Ma, Xiaoxia Shi, Bohui Yan, Yu Zhou, Can Standard versus extralevator abdominoperineal excision and oncologic outcomes for patients with distal rectal cancer: A meta-analysis |
title | Standard versus extralevator abdominoperineal excision and oncologic outcomes for patients with distal rectal cancer: A meta-analysis |
title_full | Standard versus extralevator abdominoperineal excision and oncologic outcomes for patients with distal rectal cancer: A meta-analysis |
title_fullStr | Standard versus extralevator abdominoperineal excision and oncologic outcomes for patients with distal rectal cancer: A meta-analysis |
title_full_unstemmed | Standard versus extralevator abdominoperineal excision and oncologic outcomes for patients with distal rectal cancer: A meta-analysis |
title_short | Standard versus extralevator abdominoperineal excision and oncologic outcomes for patients with distal rectal cancer: A meta-analysis |
title_sort | standard versus extralevator abdominoperineal excision and oncologic outcomes for patients with distal rectal cancer: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393134/ https://www.ncbi.nlm.nih.gov/pubmed/29384902 http://dx.doi.org/10.1097/MD.0000000000009150 |
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