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Central nervous system leukemia in a patient with concurrent nasopharyngeal carcinoma and acute myeloid leukaemia: A case report

RATIONALE: Concurrent case of nasopharyngeal carcinoma (NPC) and acute myeloid leukemia (AML) has not been reported. Here, we report a case of NPC, who was concurrently suffered from AML one mother after the NPC diagnosis. PATIENT CONCERNS: The patient was a 45-year-old male who presented with a mas...

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Autores principales: Liu, Jun-Qing, Mai, Wen-Yuan, Wang, Si-Ben, Lou, Yin-Jun, Yan, Sen-Xiang, Jin, Jie, Xu, Wei-Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393157/
https://www.ncbi.nlm.nih.gov/pubmed/29384905
http://dx.doi.org/10.1097/MD.0000000000009199
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author Liu, Jun-Qing
Mai, Wen-Yuan
Wang, Si-Ben
Lou, Yin-Jun
Yan, Sen-Xiang
Jin, Jie
Xu, Wei-Lai
author_facet Liu, Jun-Qing
Mai, Wen-Yuan
Wang, Si-Ben
Lou, Yin-Jun
Yan, Sen-Xiang
Jin, Jie
Xu, Wei-Lai
author_sort Liu, Jun-Qing
collection PubMed
description RATIONALE: Concurrent case of nasopharyngeal carcinoma (NPC) and acute myeloid leukemia (AML) has not been reported. Here, we report a case of NPC, who was concurrently suffered from AML one mother after the NPC diagnosis. PATIENT CONCERNS: The patient was a 45-year-old male who presented with a mass on his right side neck. DIAGNOSES: The patient was diagnosed with Epstein–Barr virus negative type-2 non-keratinizing carcinoma with clivus involvement and unilateral metastasis to the cervical lymph node. INTERVENTIONS: He was treated with one cycle of cisplatin and 69.76 Gy of concurrent external-beam radiation. OUTCOMES: Three months after completion of chemo-radiotherapy, the patient was diagnosed as acute myeloid leukemia, which achieved complete remission after one course induction chemotherapy. Two months later, however, the patient was diagnosed as central nervous system leukemia. He ultimately died of relapsed leukemia. The overall survival of the patient was 10 months. LESSONS: The co-occurrence of NPC and AML is rare and prognosis is poor. Radiotherapy in NPC can disrupt the blood-brain barrier, which may contribute to the pathogenesis of central nervous system leukemia. Early alert and prevention of central nervous system leukemia following radiotherapy in NPC patient is recommended.
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spelling pubmed-63931572019-03-15 Central nervous system leukemia in a patient with concurrent nasopharyngeal carcinoma and acute myeloid leukaemia: A case report Liu, Jun-Qing Mai, Wen-Yuan Wang, Si-Ben Lou, Yin-Jun Yan, Sen-Xiang Jin, Jie Xu, Wei-Lai Medicine (Baltimore) Research Article RATIONALE: Concurrent case of nasopharyngeal carcinoma (NPC) and acute myeloid leukemia (AML) has not been reported. Here, we report a case of NPC, who was concurrently suffered from AML one mother after the NPC diagnosis. PATIENT CONCERNS: The patient was a 45-year-old male who presented with a mass on his right side neck. DIAGNOSES: The patient was diagnosed with Epstein–Barr virus negative type-2 non-keratinizing carcinoma with clivus involvement and unilateral metastasis to the cervical lymph node. INTERVENTIONS: He was treated with one cycle of cisplatin and 69.76 Gy of concurrent external-beam radiation. OUTCOMES: Three months after completion of chemo-radiotherapy, the patient was diagnosed as acute myeloid leukemia, which achieved complete remission after one course induction chemotherapy. Two months later, however, the patient was diagnosed as central nervous system leukemia. He ultimately died of relapsed leukemia. The overall survival of the patient was 10 months. LESSONS: The co-occurrence of NPC and AML is rare and prognosis is poor. Radiotherapy in NPC can disrupt the blood-brain barrier, which may contribute to the pathogenesis of central nervous system leukemia. Early alert and prevention of central nervous system leukemia following radiotherapy in NPC patient is recommended. Wolters Kluwer Health 2017-12-29 /pmc/articles/PMC6393157/ /pubmed/29384905 http://dx.doi.org/10.1097/MD.0000000000009199 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Liu, Jun-Qing
Mai, Wen-Yuan
Wang, Si-Ben
Lou, Yin-Jun
Yan, Sen-Xiang
Jin, Jie
Xu, Wei-Lai
Central nervous system leukemia in a patient with concurrent nasopharyngeal carcinoma and acute myeloid leukaemia: A case report
title Central nervous system leukemia in a patient with concurrent nasopharyngeal carcinoma and acute myeloid leukaemia: A case report
title_full Central nervous system leukemia in a patient with concurrent nasopharyngeal carcinoma and acute myeloid leukaemia: A case report
title_fullStr Central nervous system leukemia in a patient with concurrent nasopharyngeal carcinoma and acute myeloid leukaemia: A case report
title_full_unstemmed Central nervous system leukemia in a patient with concurrent nasopharyngeal carcinoma and acute myeloid leukaemia: A case report
title_short Central nervous system leukemia in a patient with concurrent nasopharyngeal carcinoma and acute myeloid leukaemia: A case report
title_sort central nervous system leukemia in a patient with concurrent nasopharyngeal carcinoma and acute myeloid leukaemia: a case report
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393157/
https://www.ncbi.nlm.nih.gov/pubmed/29384905
http://dx.doi.org/10.1097/MD.0000000000009199
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