A coronary artery disease-associated tRNA(Thr) mutation altered mitochondrial function, apoptosis and angiogenesis

The tissue specificity of mitochondrial tRNA mutations remains largely elusive. In this study, we demonstrated the deleterious effects of tRNA(Thr) 15927G>A mutation that contributed to pathogenesis of coronary artery disease. The m.15927G>A mutation abolished the highly conserved base-pairing...

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Detalles Bibliográficos
Autores principales: Jia, Zidong, Zhang, Ye, Li, Qiang, Ye, Zhenzhen, Liu, Yuqi, Fu, Changzhu, Cang, Xiaohui, Wang, Meng, Guan, Min-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393294/
https://www.ncbi.nlm.nih.gov/pubmed/30541130
http://dx.doi.org/10.1093/nar/gky1241

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