Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket

The DNA binding domain (DBD) of the tumor suppressor p53 is the site of several oncogenic mutations. A subset of these mutations lowers the unfolding temperature of the DBD. Unfolding leads to the exposure of a hydrophobic β-strand and nucleates aggregation which results in pathologies through loss...

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Detalles Bibliográficos
Autores principales: Pradhan, Mohan R, Siau, Jia Wei, Kannan, Srinivasaraghavan, Nguyen, Minh N, Ouaray, Zohra, Kwoh, Chee Keong, Lane, David P, Ghadessy, Farid, Verma, Chandra S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393305/
https://www.ncbi.nlm.nih.gov/pubmed/30649466
http://dx.doi.org/10.1093/nar/gky1314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393305/
https://www.ncbi.nlm.nih.gov/pubmed/30649466
http://dx.doi.org/10.1093/nar/gky1314

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