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L-4, a Well-Tolerated and Orally Active Inhibitor of Hedgehog Pathway, Exhibited Potent Anti-tumor Effects Against Medulloblastoma in vitro and in vivo

Inhibition of aberrant Hedgehog (Hh) pathway had been proved to be a promising therapeutic intervention in cancers like basal cell carcinoma (BCC), medulloblastoma (MB), and so on. Two drugs (Vismodegib, Sonidegib) were approved to treat BCC and more inhibitors are in clinical investigation. However...

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Detalles Bibliográficos
Autores principales:	Zhu, Mingfei, Wang, Hong, Wang, Chenglin, Fang, Yanfen, Zhu, Tong, Zhao, Weili, Dong, Xiaochun, Zhang, Xiongwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393386/ https://www.ncbi.nlm.nih.gov/pubmed/30846937 http://dx.doi.org/10.3389/fphar.2019.00089

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