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A Novel Optical Scanning Technique with an Inclined Focusing Plane

We propose a novel technique for fully automated optical scanning of thin samples. We analyze its performance and estimate the achievable scanning speed to compare it with conventional techniques. It paves the way to the next generation of highspeed scalable scanning systems, at least one order of m...

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Detalles Bibliográficos
Autores principales: Alexandrov, Andrey, De Lellis, Giovanni, Tioukov, Valeri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393444/
https://www.ncbi.nlm.nih.gov/pubmed/30814578
http://dx.doi.org/10.1038/s41598-019-39415-8
Descripción
Sumario:We propose a novel technique for fully automated optical scanning of thin samples. We analyze its performance and estimate the achievable scanning speed to compare it with conventional techniques. It paves the way to the next generation of highspeed scalable scanning systems, at least one order of magnitude faster than existing ones. We show that the efficiency and the accuracy of this new technique are comparable to those of the conventional ones, while the scanning speed scales proportionally with the number of cameras installed, hence the large expected improvement.