ISL1 predicts poor outcomes for patients with gastric cancer and drives tumor progression through binding to the ZEB1 promoter together with SETD7

ISL1, a LIM-homeodomain transcription factor, serves as a biomarker of metastasis in multiple tumors. However, the function and underlying mechanisms of ISL1 in gastric cancer (GC) have not been fully elucidated. Here we found that ISL1 was frequently overexpressed in GC FFPE samples (104/196, 53.06...

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Detalles Bibliográficos
Autores principales: Guo, Ting, Wen, Xian-Zi, Li, Zi-yu, Han, Hai-bo, Zhang, Chen-guang, Bai, Yan-hua, Xing, Xiao-Fang, Cheng, Xiao-jing, Du, Hong, Hu, Ying, Wang, Xiao-Hong, Jia, Yong-Ning, Nie, Meng-Lin, Xie, Meng, Li, Qing-Da, Ji, Jia-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393520/
https://www.ncbi.nlm.nih.gov/pubmed/30674889
http://dx.doi.org/10.1038/s41419-018-1278-2

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