The intracellular domain of β-dystroglycan mediates the nucleolar stress response by suppressing UBF transcriptional activity

β-dystroglycan (β-DG) is a key component of multiprotein complexes in the plasma membrane and nuclear envelope. In addition, β-DG undergoes two successive proteolytic cleavages that result in the liberation of its intracellular domain (ICD) into the cytosol and nucleus. However, stimuli-inducing ICD...

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Detalles Bibliográficos
Autores principales: Azuara-Medina, Paulina Margarita, Sandoval-Duarte, Ariana María, Morales-Lázaro, Sara L., Modragón-González, Ricardo, Vélez-Aguilera, Griselda, Gómez-López, Juan de Dios, Jiménez-Gutiérrez, Guadalupe Elizabeth, Tiburcio-Félix, Reynaldo, Martínez-Vieyra, Ivette, Suárez-Sánchez, Rocío, Längst, Gernot, Magaña, Jonathan Javier, Winder, Steve J., Ortega, Arturo, Ramos Perlingeiro, Rita de Cassia, Jacobs, Laura A., Cisneros, Bulmaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393529/
https://www.ncbi.nlm.nih.gov/pubmed/30814495
http://dx.doi.org/10.1038/s41419-019-1454-z

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