Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice

Phosphorylation of the translation initiation factor eIF2α within the mediobasal hypothalamus is known to suppress food intake, but the role of the eIF2α phosphatases in regulating body weight is poorly understood. Mice deficient in active PPP1R15A, a stress-inducible eIF2α phosphatase, are healthy...

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Detalles Bibliográficos
Autores principales: Patel, Vruti, Bidault, Guillaume, Chambers, Joseph E., Carobbio, Stefania, Everden, Angharad J. T., Garcés, Concepción, Dalton, Lucy E., Gribble, Fiona M., Vidal-Puig, Antonio, Marciniak, Stefan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393541/
https://www.ncbi.nlm.nih.gov/pubmed/30814564
http://dx.doi.org/10.1038/s41598-019-39562-y

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