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Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis

The stem cell pluripotency factor Oct4 serves a critical protective role during atherosclerotic plaque development by promoting smooth muscle cell (SMC) investment. Here, we show using Myh11-CreER(T2) lineage-tracing with inducible SMC and pericyte (SMC-P) knockout of Oct4 that Oct4 regulates periva...

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Detalles Bibliográficos
Autores principales:	Hess, Daniel L., Kelly-Goss, Molly R., Cherepanova, Olga A., Nguyen, Anh T., Baylis, Richard A., Tkachenko, Svyatoslav, Annex, Brian H., Peirce, Shayn M., Owens, Gary K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393549/ https://www.ncbi.nlm.nih.gov/pubmed/30814500 http://dx.doi.org/10.1038/s41467-019-08811-z

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