Rationally designed carbohydrate-occluded epitopes elicit HIV-1 Env-specific antibodies

An array of carbohydrates masks the HIV-1 surface protein Env, contributing to the evasion of humoral immunity. In most HIV-1 isolates ‘glycan holes’ occur due to natural sequence variation, potentially revealing the underlying protein surface to the immune system. Here we computationally design epi...

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Detalles Bibliográficos
Autores principales: Zhu, Cheng, Dukhovlinova, Elena, Council, Olivia, Ping, Lihua, Faison, Edgar M., Prabhu, Shamit S., Potter, E. Lake, Upton, Stephen L., Yin, Guowei, Fay, James M., Kincer, Laura P., Spielvogel, Ean, Campbell, Sharon L., Benhabbour, S. Rahima, Ke, Hengming, Swanstrom, Ronald, Dokholyan, Nikolay V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393580/
https://www.ncbi.nlm.nih.gov/pubmed/30814513
http://dx.doi.org/10.1038/s41467-019-08876-w

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