Insulin secretory granules labelled with phogrin-fluorescent proteins show alterations in size, mobility and responsiveness to glucose stimulation in living β-cells

The intracellular life of insulin secretory granules (ISGs) from biogenesis to secretion depends on their structural (e.g. size) and dynamic (e.g. diffusivity, mode of motion) properties. Thus, it would be useful to have rapid and robust measurements of such parameters in living β-cells. To provide...

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Detalles Bibliográficos
Autores principales: Ferri, Gianmarco, Digiacomo, Luca, Lavagnino, Zeno, Occhipinti, Margherita, Bugliani, Marco, Cappello, Valentina, Caracciolo, Giulio, Marchetti, Piero, Piston, David W., Cardarelli, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393586/
https://www.ncbi.nlm.nih.gov/pubmed/30814595
http://dx.doi.org/10.1038/s41598-019-39329-5

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