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The impact of fasting on resting state brain networks in mice

Fasting is known to influence learning and memory in mice and alter the neural networks that subserve these cognitive functions. We used high-resolution functional MRI to study the impact of fasting on resting-state functional connectivity in mice following 12 h of fasting. The cortex and subcortex...

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Autores principales: Tsurugizawa, Tomokazu, Djemai, Boucif, Zalesky, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393589/
https://www.ncbi.nlm.nih.gov/pubmed/30814613
http://dx.doi.org/10.1038/s41598-019-39851-6
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author Tsurugizawa, Tomokazu
Djemai, Boucif
Zalesky, Andrew
author_facet Tsurugizawa, Tomokazu
Djemai, Boucif
Zalesky, Andrew
author_sort Tsurugizawa, Tomokazu
collection PubMed
description Fasting is known to influence learning and memory in mice and alter the neural networks that subserve these cognitive functions. We used high-resolution functional MRI to study the impact of fasting on resting-state functional connectivity in mice following 12 h of fasting. The cortex and subcortex were parcellated into 52 subregions and functional connectivity was measured between each pair of subregions in groups of fasted and non-fasted mice. Functional connectivity was globally increased in the fasted group compared to the non-fasted group, with the most significant increases evident between the hippocampus (bilateral), retrosplenial cortex (left), visual cortex (left) and auditory cortex (left). Functional brain networks in the non-fasted group comprised five segregated modules of strongly interconnected subregions, whereas the fasted group comprised only three modules. The amplitude of low frequency fluctuations (ALFF) was decreased in the ventromedial hypothalamus in the fasted group. Correlation in gamma oscillations derived from local field potentials was increased between the left visual and retrosplenial cortices in the fasted group and the power of gamma oscillations was reduced in the ventromedial hypothalamus. These results indicate that fasting induces profound changes in functional connectivity, most likely resulting from altered coupling of neuronal gamma oscillations.
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spelling pubmed-63935892019-03-01 The impact of fasting on resting state brain networks in mice Tsurugizawa, Tomokazu Djemai, Boucif Zalesky, Andrew Sci Rep Article Fasting is known to influence learning and memory in mice and alter the neural networks that subserve these cognitive functions. We used high-resolution functional MRI to study the impact of fasting on resting-state functional connectivity in mice following 12 h of fasting. The cortex and subcortex were parcellated into 52 subregions and functional connectivity was measured between each pair of subregions in groups of fasted and non-fasted mice. Functional connectivity was globally increased in the fasted group compared to the non-fasted group, with the most significant increases evident between the hippocampus (bilateral), retrosplenial cortex (left), visual cortex (left) and auditory cortex (left). Functional brain networks in the non-fasted group comprised five segregated modules of strongly interconnected subregions, whereas the fasted group comprised only three modules. The amplitude of low frequency fluctuations (ALFF) was decreased in the ventromedial hypothalamus in the fasted group. Correlation in gamma oscillations derived from local field potentials was increased between the left visual and retrosplenial cortices in the fasted group and the power of gamma oscillations was reduced in the ventromedial hypothalamus. These results indicate that fasting induces profound changes in functional connectivity, most likely resulting from altered coupling of neuronal gamma oscillations. Nature Publishing Group UK 2019-02-27 /pmc/articles/PMC6393589/ /pubmed/30814613 http://dx.doi.org/10.1038/s41598-019-39851-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Tsurugizawa, Tomokazu
Djemai, Boucif
Zalesky, Andrew
The impact of fasting on resting state brain networks in mice
title The impact of fasting on resting state brain networks in mice
title_full The impact of fasting on resting state brain networks in mice
title_fullStr The impact of fasting on resting state brain networks in mice
title_full_unstemmed The impact of fasting on resting state brain networks in mice
title_short The impact of fasting on resting state brain networks in mice
title_sort impact of fasting on resting state brain networks in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393589/
https://www.ncbi.nlm.nih.gov/pubmed/30814613
http://dx.doi.org/10.1038/s41598-019-39851-6
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