HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression

Histone deacetylases (HDACs) are promising targets for cancer therapy, although their individual actions remain incompletely understood. Here, we identify a role for HDAC2 in the regulation of MDM2 acetylation at previously uncharacterized lysines. Upon inactivation of HDAC2, this acetylation create...

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Detalles Bibliográficos
Autores principales: Patel, Nikita, Wang, Juehong, Shiozawa, Kumiko, Jones, Kevin B., Zhang, Yanfeng, Prokop, Jeremy W., Davenport, George G., Nihira, Naoe T., Hao, Zhenyue, Wong, Derek, Brandsmeier, Laurel, Meadows, Sarah K., Sampaio, Arthur V., Werff, Ryan Vander, Endo, Makoto, Capecchi, Mario R., McNagny, Kelly M., Mak, Tak W., Nielsen, Torsten O., Underhill, T. Michael, Myers, Richard M., Kondo, Tadashi, Su, Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393697/
https://www.ncbi.nlm.nih.gov/pubmed/30818224
http://dx.doi.org/10.1016/j.isci.2019.02.008

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