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Whole-brain magnetic resonance imaging of plaque burden and lenticulostriate arteries in patients with different types of stroke

BACKGROUND: Large-vessel atherosclerotic disease is an important pathogenesis of deep-perforator infarction (DPI). However, altered vessel walls of intracranial large arteries and distribution of small arteries in DPI are unclear because of the limited resolution of current imaging techniques. In th...

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Autores principales: Wu, Fang, Zhang, Qian, Dong, Kai, Duan, Jiangang, Yang, Xiaoxu, Wu, Ye, Zhang, Ling, Li, Debiao, Fan, Zhaoyang, Yang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393832/
https://www.ncbi.nlm.nih.gov/pubmed/30833987
http://dx.doi.org/10.1177/1756286419833295
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author Wu, Fang
Zhang, Qian
Dong, Kai
Duan, Jiangang
Yang, Xiaoxu
Wu, Ye
Zhang, Ling
Li, Debiao
Fan, Zhaoyang
Yang, Qi
author_facet Wu, Fang
Zhang, Qian
Dong, Kai
Duan, Jiangang
Yang, Xiaoxu
Wu, Ye
Zhang, Ling
Li, Debiao
Fan, Zhaoyang
Yang, Qi
author_sort Wu, Fang
collection PubMed
description BACKGROUND: Large-vessel atherosclerotic disease is an important pathogenesis of deep-perforator infarction (DPI). However, altered vessel walls of intracranial large arteries and distribution of small arteries in DPI are unclear because of the limited resolution of current imaging techniques. In this study the intracranial plaque burden and lenticulostriate artery (LSA) distribution in patients with recent DPI and non-DPI using whole-brain vessel-wall imaging (WB-VWI) were investigated. METHODS: A total of 44 patients with recent DPI (23 patients) or non-DPI (21 patients) due to intracranial atherosclerotic disease were prospectively enrolled. WB-VWI was performed in all the patients using a three-dimensional T1-weighted vessel-wall magnetic resonance technique. Hemispheres with DPI and non-DPI were considered as the DPI group and non-DPI group, respectively. Hemispheres without a history of stroke were the control group. The intracranial plaque burden was compared between the DPI and non-DPI groups. The number and length of visualized LSA branches among DPI, non-DPI, and control groups were also evaluated. RESULTS: A total of 77 hemispheres were analyzed (23 in the DPI group, 21 in the non-DPI group, and 33 in the control group). Plaque burden was lower (p = 0.047) in the DPI group (82.0 ± 45.9 mm(3)) compared with the non-DPI group (130.9 ± 90.3 mm(3)). There was a significant reduction (p = 0.002) in length of visualized LSA branches in the DPI group (74.1 ± 21.7 mm) compared with the control group (104.6 ± 33.3 mm). CONCLUSIONS: WB-VWI enables the combination of vessel-wall and LSA imaging in one image setting, which can provide information about plaque burden and LSA distribution.
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spelling pubmed-63938322019-03-04 Whole-brain magnetic resonance imaging of plaque burden and lenticulostriate arteries in patients with different types of stroke Wu, Fang Zhang, Qian Dong, Kai Duan, Jiangang Yang, Xiaoxu Wu, Ye Zhang, Ling Li, Debiao Fan, Zhaoyang Yang, Qi Ther Adv Neurol Disord Original Research BACKGROUND: Large-vessel atherosclerotic disease is an important pathogenesis of deep-perforator infarction (DPI). However, altered vessel walls of intracranial large arteries and distribution of small arteries in DPI are unclear because of the limited resolution of current imaging techniques. In this study the intracranial plaque burden and lenticulostriate artery (LSA) distribution in patients with recent DPI and non-DPI using whole-brain vessel-wall imaging (WB-VWI) were investigated. METHODS: A total of 44 patients with recent DPI (23 patients) or non-DPI (21 patients) due to intracranial atherosclerotic disease were prospectively enrolled. WB-VWI was performed in all the patients using a three-dimensional T1-weighted vessel-wall magnetic resonance technique. Hemispheres with DPI and non-DPI were considered as the DPI group and non-DPI group, respectively. Hemispheres without a history of stroke were the control group. The intracranial plaque burden was compared between the DPI and non-DPI groups. The number and length of visualized LSA branches among DPI, non-DPI, and control groups were also evaluated. RESULTS: A total of 77 hemispheres were analyzed (23 in the DPI group, 21 in the non-DPI group, and 33 in the control group). Plaque burden was lower (p = 0.047) in the DPI group (82.0 ± 45.9 mm(3)) compared with the non-DPI group (130.9 ± 90.3 mm(3)). There was a significant reduction (p = 0.002) in length of visualized LSA branches in the DPI group (74.1 ± 21.7 mm) compared with the control group (104.6 ± 33.3 mm). CONCLUSIONS: WB-VWI enables the combination of vessel-wall and LSA imaging in one image setting, which can provide information about plaque burden and LSA distribution. SAGE Publications 2019-02-26 /pmc/articles/PMC6393832/ /pubmed/30833987 http://dx.doi.org/10.1177/1756286419833295 Text en © The Author(s), 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Wu, Fang
Zhang, Qian
Dong, Kai
Duan, Jiangang
Yang, Xiaoxu
Wu, Ye
Zhang, Ling
Li, Debiao
Fan, Zhaoyang
Yang, Qi
Whole-brain magnetic resonance imaging of plaque burden and lenticulostriate arteries in patients with different types of stroke
title Whole-brain magnetic resonance imaging of plaque burden and lenticulostriate arteries in patients with different types of stroke
title_full Whole-brain magnetic resonance imaging of plaque burden and lenticulostriate arteries in patients with different types of stroke
title_fullStr Whole-brain magnetic resonance imaging of plaque burden and lenticulostriate arteries in patients with different types of stroke
title_full_unstemmed Whole-brain magnetic resonance imaging of plaque burden and lenticulostriate arteries in patients with different types of stroke
title_short Whole-brain magnetic resonance imaging of plaque burden and lenticulostriate arteries in patients with different types of stroke
title_sort whole-brain magnetic resonance imaging of plaque burden and lenticulostriate arteries in patients with different types of stroke
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393832/
https://www.ncbi.nlm.nih.gov/pubmed/30833987
http://dx.doi.org/10.1177/1756286419833295
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