Control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogens

Enterohaemorrhagic Escherichia coli (EHEC) mediates disease using a type 3 secretion system (T3SS), which is encoded on the locus of enterocyte effacement (LEE) and is tightly controlled by master regulators. This system is further modulated by a number of signals that help to fine-tune virulence, i...

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Detalles Bibliográficos
Autores principales: Turner, Natasha C.A., Connolly, James P.R., Roe, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393859/
https://www.ncbi.nlm.nih.gov/pubmed/30559275
http://dx.doi.org/10.1042/BST20180546
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author Turner, Natasha C.A.
Connolly, James P.R.
Roe, Andrew J.
author_facet Turner, Natasha C.A.
Connolly, James P.R.
Roe, Andrew J.
author_sort Turner, Natasha C.A.
collection PubMed
description Enterohaemorrhagic Escherichia coli (EHEC) mediates disease using a type 3 secretion system (T3SS), which is encoded on the locus of enterocyte effacement (LEE) and is tightly controlled by master regulators. This system is further modulated by a number of signals that help to fine-tune virulence, including metabolic, environmental and chemical signals. Since the LEE and its master regulator, Ler, were established, there have been numerous scientific advancements in understanding the regulation and expression of virulence factors in EHEC. This review will discuss the recent advancements in this field since our previous review, with a focus on the transcriptional regulation of the LEE.
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spelling pubmed-63938592019-03-06 Control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogens Turner, Natasha C.A. Connolly, James P.R. Roe, Andrew J. Biochem Soc Trans Review Articles Enterohaemorrhagic Escherichia coli (EHEC) mediates disease using a type 3 secretion system (T3SS), which is encoded on the locus of enterocyte effacement (LEE) and is tightly controlled by master regulators. This system is further modulated by a number of signals that help to fine-tune virulence, including metabolic, environmental and chemical signals. Since the LEE and its master regulator, Ler, were established, there have been numerous scientific advancements in understanding the regulation and expression of virulence factors in EHEC. This review will discuss the recent advancements in this field since our previous review, with a focus on the transcriptional regulation of the LEE. Portland Press Ltd. 2019-02-28 2018-12-17 /pmc/articles/PMC6393859/ /pubmed/30559275 http://dx.doi.org/10.1042/BST20180546 Text en © 2019 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Turner, Natasha C.A.
Connolly, James P.R.
Roe, Andrew J.
Control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogens
title Control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogens
title_full Control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogens
title_fullStr Control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogens
title_full_unstemmed Control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogens
title_short Control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogens
title_sort control freaks—signals and cues governing the regulation of virulence in attaching and effacing pathogens
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393859/
https://www.ncbi.nlm.nih.gov/pubmed/30559275
http://dx.doi.org/10.1042/BST20180546
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