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BuShenKangShuai Tablet Alleviates Hepatic Steatosis via Improving Liver Adiponectin Resistance in ApoE(−/−) Mice
BuShenKangShuai tablet (BSKS) is a Chinese herbal compound, which has been used to treat nonalcoholic fatty liver disease and cardiovascular diseases in clinic for over four decades. This study intends to explore whether BSKS administration can alleviates hepatic steatosis via improving liver adipon...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393934/ https://www.ncbi.nlm.nih.gov/pubmed/30894877 http://dx.doi.org/10.1155/2019/8986038 |
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author | Pang, Shu-chao Wang, Shuo Chen, Mei-ling Zhang, Jun-ping Wang, Yuan-yuan Jia, Hui-yun Bi, Li-yuan Wang, Hui |
author_facet | Pang, Shu-chao Wang, Shuo Chen, Mei-ling Zhang, Jun-ping Wang, Yuan-yuan Jia, Hui-yun Bi, Li-yuan Wang, Hui |
author_sort | Pang, Shu-chao |
collection | PubMed |
description | BuShenKangShuai tablet (BSKS) is a Chinese herbal compound, which has been used to treat nonalcoholic fatty liver disease and cardiovascular diseases in clinic for over four decades. This study intends to explore whether BSKS administration can alleviates hepatic steatosis via improving liver adiponectin resistance in ApoE(−/−) mice. ApoE(−/−) mice were fed with western-type diet for 6 weeks and then were administrated with BSKS or atorvastatin for 6 weeks by gavage, and then blood and liver were collected for analysis. The results showed that BSKS attenuated hepatic steatosis, decreased blood lipids, and increased the serum level of adiponectin. We also found that adiponectin resistance in the liver was improved by BSKS, while the expression of TLR4 and NF-κB p65 was inhibited, followed by the suppression of proinflammatory mediators of TNF-α. Our data provided evidence that BSKS was able to alleviate hepatic steatosis in vivo. The underlying mechanism of BSKS was focused on improving liver adiponectin resistance, thereby regulating dyslipidemia and inhibiting inflammatory signaling pathway. |
format | Online Article Text |
id | pubmed-6393934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63939342019-03-20 BuShenKangShuai Tablet Alleviates Hepatic Steatosis via Improving Liver Adiponectin Resistance in ApoE(−/−) Mice Pang, Shu-chao Wang, Shuo Chen, Mei-ling Zhang, Jun-ping Wang, Yuan-yuan Jia, Hui-yun Bi, Li-yuan Wang, Hui Evid Based Complement Alternat Med Research Article BuShenKangShuai tablet (BSKS) is a Chinese herbal compound, which has been used to treat nonalcoholic fatty liver disease and cardiovascular diseases in clinic for over four decades. This study intends to explore whether BSKS administration can alleviates hepatic steatosis via improving liver adiponectin resistance in ApoE(−/−) mice. ApoE(−/−) mice were fed with western-type diet for 6 weeks and then were administrated with BSKS or atorvastatin for 6 weeks by gavage, and then blood and liver were collected for analysis. The results showed that BSKS attenuated hepatic steatosis, decreased blood lipids, and increased the serum level of adiponectin. We also found that adiponectin resistance in the liver was improved by BSKS, while the expression of TLR4 and NF-κB p65 was inhibited, followed by the suppression of proinflammatory mediators of TNF-α. Our data provided evidence that BSKS was able to alleviate hepatic steatosis in vivo. The underlying mechanism of BSKS was focused on improving liver adiponectin resistance, thereby regulating dyslipidemia and inhibiting inflammatory signaling pathway. Hindawi 2019-02-13 /pmc/articles/PMC6393934/ /pubmed/30894877 http://dx.doi.org/10.1155/2019/8986038 Text en Copyright © 2019 Shu-chao Pang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Pang, Shu-chao Wang, Shuo Chen, Mei-ling Zhang, Jun-ping Wang, Yuan-yuan Jia, Hui-yun Bi, Li-yuan Wang, Hui BuShenKangShuai Tablet Alleviates Hepatic Steatosis via Improving Liver Adiponectin Resistance in ApoE(−/−) Mice |
title | BuShenKangShuai Tablet Alleviates Hepatic Steatosis via Improving Liver Adiponectin Resistance in ApoE(−/−) Mice |
title_full | BuShenKangShuai Tablet Alleviates Hepatic Steatosis via Improving Liver Adiponectin Resistance in ApoE(−/−) Mice |
title_fullStr | BuShenKangShuai Tablet Alleviates Hepatic Steatosis via Improving Liver Adiponectin Resistance in ApoE(−/−) Mice |
title_full_unstemmed | BuShenKangShuai Tablet Alleviates Hepatic Steatosis via Improving Liver Adiponectin Resistance in ApoE(−/−) Mice |
title_short | BuShenKangShuai Tablet Alleviates Hepatic Steatosis via Improving Liver Adiponectin Resistance in ApoE(−/−) Mice |
title_sort | bushenkangshuai tablet alleviates hepatic steatosis via improving liver adiponectin resistance in apoe(−/−) mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393934/ https://www.ncbi.nlm.nih.gov/pubmed/30894877 http://dx.doi.org/10.1155/2019/8986038 |
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