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A phase II trial of the effect of perindopril on hand–foot skin reaction (HFSR) incidence and severity in patients receiving regorafenib for refractory mCRC

PURPOSE: Regorafenib is an oral multi-kinase inhibitor that offers an OS benefit to patients with mCRC refractory to standard therapy (Grothey et al., in Lancet 381:303–312, 2013), but comes with potential significant toxicities including grade 3 hand–foot skin reaction (HFSR). The pathogenesis of r...

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Detalles Bibliográficos
Autores principales:	Melosky, Barbara L., Lim, Howard John, Davies, Janine Marie, Gill, Sharlene, Kollmannsberger, Christian K., Ho, Maria Yi, Vandt, Solomon A., Renouf, Daniel John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394486/ https://www.ncbi.nlm.nih.gov/pubmed/30535909 http://dx.doi.org/10.1007/s00280-018-3738-x

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