Impact of a Heat Shock Protein Impurity on the Immunogenicity of Biotherapeutic Monoclonal Antibodies

PURPOSE: Anti-drug antibodies can impair the efficacy of therapeutic proteins and, in some circumstances, induce adverse health effects. Immunogenicity can be promoted by aggregation; here we examined the ability of recombinant mouse heat shock protein 70 (rmHSP70) - a common host cell impurity - to...

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Detalles Bibliográficos
Autores principales: Rane, Shraddha S., Dearman, Rebecca J., Kimber, Ian, Uddin, Shahid, Bishop, Stephen, Shah, Maryam, Podmore, Adrian, Pluen, Alain, Derrick, Jeremy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394513/
https://www.ncbi.nlm.nih.gov/pubmed/30771015
http://dx.doi.org/10.1007/s11095-019-2586-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394513/
https://www.ncbi.nlm.nih.gov/pubmed/30771015
http://dx.doi.org/10.1007/s11095-019-2586-7

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