Tissue Plasminogen Activator Causes Brain Microvascular Endothelial Cell Injury After Oxygen Glucose Deprivation by Inhibiting Sonic Hedgehog Signaling

The thrombolytic activity of tissue plasminogen activator (tPA) has undisputed benefits. However, the documented neurotoxicity of tPA raises important issues. Currently, common treatments for stroke might not be optimum if exogenous tPA can pass through the blood–brain barrier and enter the brain, t...

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Detalles Bibliográficos
Autores principales: Gong, Pian, Li, Mingchang, Zou, Changlin, Tian, Qi, Xu, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394519/
https://www.ncbi.nlm.nih.gov/pubmed/30552546
http://dx.doi.org/10.1007/s11064-018-2697-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394519/
https://www.ncbi.nlm.nih.gov/pubmed/30552546
http://dx.doi.org/10.1007/s11064-018-2697-2

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