H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism

miR-424(322)/-503 are mammal-specific members of the extended miR-15/107 microRNA family. They form a co-expression network with the imprinted lncRNA H19 in tetrapods. miR-424(322)/-503 regulate fundamental cellular processes including cell cycle, epithelial-to-mesenchymal transition, hypoxia and ot...

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Autores principales: Wang, Fan, Liang, Rui, Tandon, Neha, Matthews, Elizabeth R., Shrestha, Shreesti, Yang, Jiao, Soibam, Benjamin, Yang, Jin, Liu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394552/
https://www.ncbi.nlm.nih.gov/pubmed/30474694
http://dx.doi.org/10.1007/s00018-018-2971-0
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author Wang, Fan
Liang, Rui
Tandon, Neha
Matthews, Elizabeth R.
Shrestha, Shreesti
Yang, Jiao
Soibam, Benjamin
Yang, Jin
Liu, Yu
author_facet Wang, Fan
Liang, Rui
Tandon, Neha
Matthews, Elizabeth R.
Shrestha, Shreesti
Yang, Jiao
Soibam, Benjamin
Yang, Jin
Liu, Yu
author_sort Wang, Fan
collection PubMed
description miR-424(322)/-503 are mammal-specific members of the extended miR-15/107 microRNA family. They form a co-expression network with the imprinted lncRNA H19 in tetrapods. miR-424(322)/-503 regulate fundamental cellular processes including cell cycle, epithelial-to-mesenchymal transition, hypoxia and other stress response. They control tissue differentiation (cardiomyocyte, skeletal muscle, monocyte) and remodeling (mammary gland involution), and paradoxically participate in tumor initiation and progression. Expression of miR-424(322)/-503 is governed by unique mechanisms involving sex hormones. Here, we summarize current literature and provide a primer for future endeavors.
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spelling pubmed-63945522019-03-15 H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism Wang, Fan Liang, Rui Tandon, Neha Matthews, Elizabeth R. Shrestha, Shreesti Yang, Jiao Soibam, Benjamin Yang, Jin Liu, Yu Cell Mol Life Sci Review miR-424(322)/-503 are mammal-specific members of the extended miR-15/107 microRNA family. They form a co-expression network with the imprinted lncRNA H19 in tetrapods. miR-424(322)/-503 regulate fundamental cellular processes including cell cycle, epithelial-to-mesenchymal transition, hypoxia and other stress response. They control tissue differentiation (cardiomyocyte, skeletal muscle, monocyte) and remodeling (mammary gland involution), and paradoxically participate in tumor initiation and progression. Expression of miR-424(322)/-503 is governed by unique mechanisms involving sex hormones. Here, we summarize current literature and provide a primer for future endeavors. Springer International Publishing 2018-11-24 2019 /pmc/articles/PMC6394552/ /pubmed/30474694 http://dx.doi.org/10.1007/s00018-018-2971-0 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Wang, Fan
Liang, Rui
Tandon, Neha
Matthews, Elizabeth R.
Shrestha, Shreesti
Yang, Jiao
Soibam, Benjamin
Yang, Jin
Liu, Yu
H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism
title H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism
title_full H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism
title_fullStr H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism
title_full_unstemmed H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism
title_short H19X-encoded miR-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism
title_sort h19x-encoded mir-424(322)/-503 cluster: emerging roles in cell differentiation, proliferation, plasticity and metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394552/
https://www.ncbi.nlm.nih.gov/pubmed/30474694
http://dx.doi.org/10.1007/s00018-018-2971-0
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