Pharmacokinetics of Tramadol and Celecoxib in Japanese and Caucasian Subjects Following Administration of Co-Crystal of Tramadol-Celecoxib (CTC): A Randomised, Open-Label Study

BACKGROUND AND OBJECTIVES: Co-Crystal of Tramadol-Celecoxib (CTC) is a first-in-class active pharmaceutical ingredient (API–API) co-crystal of rac-tramadol.HCl and celecoxib in a 1:1 molecular ratio (100 mg CTC: 44 mg rac-tramadol.HCl and 56 mg celecoxib). Tramadol and celecoxib pharmacokinetics are...

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Detalles Bibliográficos
Autores principales: Dooner, Helen, Mundin, Gill, Mersmann, Sabine, Bennett, Carla, Lorch, Ulrike, Encabo, Mercedes, Escriche, Marisol, Encina, Gregorio, Smith, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394644/
https://www.ncbi.nlm.nih.gov/pubmed/29956215
http://dx.doi.org/10.1007/s13318-018-0491-9

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