E-cadherin-deficient cells have synthetic lethal vulnerabilities in plasma membrane organisation, dynamics and function

BACKGROUND: The E-cadherin gene (CDH1) is frequently mutated in diffuse gastric cancer and lobular breast cancer, and germline mutations predispose to the cancer syndrome Hereditary Diffuse Gastric Cancer. We are taking a synthetic lethal approach to identify druggable vulnerabilities in CDH1-mutant...

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Detalles Bibliográficos
Autores principales: Godwin, Tanis D., Kelly, S. Thomas, Brew, Tom P., Bougen-Zhukov, Nicola M., Single, Andrew B., Chen, Augustine, Stylianou, Cassie E., Harris, Lawrence D., Currie, Sophie K., Telford, Bryony J., Beetham, Henry G., Evans, Gary B., Black, Michael A., Guilford, Parry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394693/
https://www.ncbi.nlm.nih.gov/pubmed/30066183
http://dx.doi.org/10.1007/s10120-018-0859-1

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