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Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors

Fungi of the basal lineage order Mucorales are able to cause infections in animals and humans. Mucormycosis is a well-known, life-threatening disease especially in patients with a compromised immune system. The rate of mortality and morbidity caused by mucormycosis has increased rapidly during the l...

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Autores principales: Hassan, Mohamed I Abdelwahab, Voigt, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394756/
https://www.ncbi.nlm.nih.gov/pubmed/30816980
http://dx.doi.org/10.1093/mmy/myz011
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author Hassan, Mohamed I Abdelwahab
Voigt, Kerstin
author_facet Hassan, Mohamed I Abdelwahab
Voigt, Kerstin
author_sort Hassan, Mohamed I Abdelwahab
collection PubMed
description Fungi of the basal lineage order Mucorales are able to cause infections in animals and humans. Mucormycosis is a well-known, life-threatening disease especially in patients with a compromised immune system. The rate of mortality and morbidity caused by mucormycosis has increased rapidly during the last decades, especially in developing countries. The systematic, phylogenetic, and epidemiological distributions of mucoralean fungi are addressed in relation to infection in immunocompromised patients. The review highlights the current achievements in (i) diagnostics and management of mucormycosis, (ii) the study of the interaction of Mucorales with cells of the innate immune system, (iii) the assessment of the virulence of Mucorales in vertebrate and invertebrate infection models, and (iv) the determination of virulence factors that are key players in the infection process, for example, high-affinity iron permease (FTR1), spore coat protein (CotH), alkaline Rhizopus protease enzyme (ARP), ADP-ribosylation factor (ARF), dihydrolipoyl dehydrogenase, calcineurin (CaN), serine and aspartate proteases (SAPs). The present mini-review attempts to increase the awareness of these difficult-to-manage fungal infections and to encourage research in the detection of ligands and receptors as potential diagnostic parameters and drug targets.
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spelling pubmed-63947562019-03-05 Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors Hassan, Mohamed I Abdelwahab Voigt, Kerstin Med Mycol Review Article Fungi of the basal lineage order Mucorales are able to cause infections in animals and humans. Mucormycosis is a well-known, life-threatening disease especially in patients with a compromised immune system. The rate of mortality and morbidity caused by mucormycosis has increased rapidly during the last decades, especially in developing countries. The systematic, phylogenetic, and epidemiological distributions of mucoralean fungi are addressed in relation to infection in immunocompromised patients. The review highlights the current achievements in (i) diagnostics and management of mucormycosis, (ii) the study of the interaction of Mucorales with cells of the innate immune system, (iii) the assessment of the virulence of Mucorales in vertebrate and invertebrate infection models, and (iv) the determination of virulence factors that are key players in the infection process, for example, high-affinity iron permease (FTR1), spore coat protein (CotH), alkaline Rhizopus protease enzyme (ARP), ADP-ribosylation factor (ARF), dihydrolipoyl dehydrogenase, calcineurin (CaN), serine and aspartate proteases (SAPs). The present mini-review attempts to increase the awareness of these difficult-to-manage fungal infections and to encourage research in the detection of ligands and receptors as potential diagnostic parameters and drug targets. Oxford University Press 2019-04 2019-02-28 /pmc/articles/PMC6394756/ /pubmed/30816980 http://dx.doi.org/10.1093/mmy/myz011 Text en © The Author 2019. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Review Article
Hassan, Mohamed I Abdelwahab
Voigt, Kerstin
Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors
title Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors
title_full Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors
title_fullStr Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors
title_full_unstemmed Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors
title_short Pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors
title_sort pathogenicity patterns of mucormycosis: epidemiology, interaction with immune cells and virulence factors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394756/
https://www.ncbi.nlm.nih.gov/pubmed/30816980
http://dx.doi.org/10.1093/mmy/myz011
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