The endogenous cardiotonic steroid Marinobufagenin and decline in estimated glomerular filtration rate at follow-up in patients with arterial hypertension

BACKGROUND: Marinobufagenin (MBG) is an endogenous cardiotonic steroid (CTS) that inhibits the Na+/K+-ATPase. Human MBG is significantly increased in end-stage renal disease and immunization against MBG attenuates cardiovascular fibrosis in a rat model of uremic cardiomyopathy. Mineralocorticoid ant...

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Detalles Bibliográficos
Autores principales: Keppel, Martin H., Piecha, Grzegorz, März, Winfried, Cadamuro, Janne, Auer, Simon, Felder, Thomas K., Mrazek, Cornelia, Oberkofler, Hannes, Trummer, Christian, Grübler, Martin R., Schwetz, Verena, Verheyen, Nicolas, Pandis, Marlene, Borzan, Valentin, Haschke-Becher, Elisabeth, Tomaschitz, Andreas, Pilz, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394930/
https://www.ncbi.nlm.nih.gov/pubmed/30817774
http://dx.doi.org/10.1371/journal.pone.0212973

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