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Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model

Recent studies have demonstrated the immunomodulatory effects of heat-killed lactic acid bacteria. The aim of this study was to evaluate the protective effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on a model of inflammatory bowel disease (IBD). A total of 28 female NC/Nga mice were...

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Detalles Bibliográficos
Autores principales: Choi, Eun-Ju, Lee, Hyuek Jong, Kim, Wan-Jae, Han, Kwon-Il, Iwasa, Masahiro, Kobayashi, Kazumasa, Debnath, Trishna, Tang, Yujiao, Kwak, Yi-Sub, Yoon, Jin-Hwan, Kim, Eun-Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394946/
https://www.ncbi.nlm.nih.gov/pubmed/30818368
http://dx.doi.org/10.1371/journal.pone.0210854
Descripción
Sumario:Recent studies have demonstrated the immunomodulatory effects of heat-killed lactic acid bacteria. The aim of this study was to evaluate the protective effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on a model of inflammatory bowel disease (IBD). A total of 28 female NC/Nga mice were divided into 4 treatment groups. Controls were fed a normal commercial diet. In the experimental groups, colitis was induced by rectal administration of dinitrobenzene sulfonic acid. Two groups were orally administered 2 and 17 mg/kg EF-2001, respectively. EF-2001 treatment decreased the expression of several cytokines, including cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), interferon (IFN)-γ, interleukin (IL)-1β, and IL-6 in inflamed colon compared to the DNBS alone group. In addition, EF-2001 suppressed DNBS-induced colonic tissue destruction. Therefore, this study strongly suggests that EF-2001 could alleviate the inflammation associated with mouse IBD.