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Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model
Recent studies have demonstrated the immunomodulatory effects of heat-killed lactic acid bacteria. The aim of this study was to evaluate the protective effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on a model of inflammatory bowel disease (IBD). A total of 28 female NC/Nga mice were...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394946/ https://www.ncbi.nlm.nih.gov/pubmed/30818368 http://dx.doi.org/10.1371/journal.pone.0210854 |
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author | Choi, Eun-Ju Lee, Hyuek Jong Kim, Wan-Jae Han, Kwon-Il Iwasa, Masahiro Kobayashi, Kazumasa Debnath, Trishna Tang, Yujiao Kwak, Yi-Sub Yoon, Jin-Hwan Kim, Eun-Kyung |
author_facet | Choi, Eun-Ju Lee, Hyuek Jong Kim, Wan-Jae Han, Kwon-Il Iwasa, Masahiro Kobayashi, Kazumasa Debnath, Trishna Tang, Yujiao Kwak, Yi-Sub Yoon, Jin-Hwan Kim, Eun-Kyung |
author_sort | Choi, Eun-Ju |
collection | PubMed |
description | Recent studies have demonstrated the immunomodulatory effects of heat-killed lactic acid bacteria. The aim of this study was to evaluate the protective effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on a model of inflammatory bowel disease (IBD). A total of 28 female NC/Nga mice were divided into 4 treatment groups. Controls were fed a normal commercial diet. In the experimental groups, colitis was induced by rectal administration of dinitrobenzene sulfonic acid. Two groups were orally administered 2 and 17 mg/kg EF-2001, respectively. EF-2001 treatment decreased the expression of several cytokines, including cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), interferon (IFN)-γ, interleukin (IL)-1β, and IL-6 in inflamed colon compared to the DNBS alone group. In addition, EF-2001 suppressed DNBS-induced colonic tissue destruction. Therefore, this study strongly suggests that EF-2001 could alleviate the inflammation associated with mouse IBD. |
format | Online Article Text |
id | pubmed-6394946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63949462019-03-08 Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model Choi, Eun-Ju Lee, Hyuek Jong Kim, Wan-Jae Han, Kwon-Il Iwasa, Masahiro Kobayashi, Kazumasa Debnath, Trishna Tang, Yujiao Kwak, Yi-Sub Yoon, Jin-Hwan Kim, Eun-Kyung PLoS One Research Article Recent studies have demonstrated the immunomodulatory effects of heat-killed lactic acid bacteria. The aim of this study was to evaluate the protective effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on a model of inflammatory bowel disease (IBD). A total of 28 female NC/Nga mice were divided into 4 treatment groups. Controls were fed a normal commercial diet. In the experimental groups, colitis was induced by rectal administration of dinitrobenzene sulfonic acid. Two groups were orally administered 2 and 17 mg/kg EF-2001, respectively. EF-2001 treatment decreased the expression of several cytokines, including cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), interferon (IFN)-γ, interleukin (IL)-1β, and IL-6 in inflamed colon compared to the DNBS alone group. In addition, EF-2001 suppressed DNBS-induced colonic tissue destruction. Therefore, this study strongly suggests that EF-2001 could alleviate the inflammation associated with mouse IBD. Public Library of Science 2019-02-28 /pmc/articles/PMC6394946/ /pubmed/30818368 http://dx.doi.org/10.1371/journal.pone.0210854 Text en © 2019 Choi et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Choi, Eun-Ju Lee, Hyuek Jong Kim, Wan-Jae Han, Kwon-Il Iwasa, Masahiro Kobayashi, Kazumasa Debnath, Trishna Tang, Yujiao Kwak, Yi-Sub Yoon, Jin-Hwan Kim, Eun-Kyung Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model |
title | Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model |
title_full | Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model |
title_fullStr | Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model |
title_full_unstemmed | Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model |
title_short | Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model |
title_sort | enterococcus faecalis ef-2001 protects dnbs-induced inflammatory bowel disease in mice model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394946/ https://www.ncbi.nlm.nih.gov/pubmed/30818368 http://dx.doi.org/10.1371/journal.pone.0210854 |
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