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Abscopal Effect after Radiosurgery for Solitary Brain Metastasis from Non-small Cell Lung Cancer
The abscopal effect is a phenomenon relating to the treatment of metastatic cancer in which localized irradiation to a tumor concurrently causes shrinkage of tumors distant from the area of treatment. Localized radiotherapy is thought to cause anti-tumor immunologic responses that lead to regression...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395017/ https://www.ncbi.nlm.nih.gov/pubmed/30854265 http://dx.doi.org/10.7759/cureus.3777 |
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author | Hamilton, Andrew J Seid, Jerome Verdecchia, Kyle Chuba, Paul |
author_facet | Hamilton, Andrew J Seid, Jerome Verdecchia, Kyle Chuba, Paul |
author_sort | Hamilton, Andrew J |
collection | PubMed |
description | The abscopal effect is a phenomenon relating to the treatment of metastatic cancer in which localized irradiation to a tumor concurrently causes shrinkage of tumors distant from the area of treatment. Localized radiotherapy is thought to cause anti-tumor immunologic responses that lead to regression and remission of cancers distant to the initial location of treatment. We present a 47-year-old male with brain metastasis from non-small cell lung cancer (NSCLC) who went into remission following stereotactic radiosurgery treatment to a brain lesion, in the absence of systemic treatment. We discuss the novelty of this case and its importance to future research on the abscopal effect. Though it is difficult to distinguish the abscopal effect from spontaneous remission of non-targeted cancer, this report sheds insight on the potential for improving treatment for the leading cause of cancer death worldwide. |
format | Online Article Text |
id | pubmed-6395017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-63950172019-03-08 Abscopal Effect after Radiosurgery for Solitary Brain Metastasis from Non-small Cell Lung Cancer Hamilton, Andrew J Seid, Jerome Verdecchia, Kyle Chuba, Paul Cureus Radiation Oncology The abscopal effect is a phenomenon relating to the treatment of metastatic cancer in which localized irradiation to a tumor concurrently causes shrinkage of tumors distant from the area of treatment. Localized radiotherapy is thought to cause anti-tumor immunologic responses that lead to regression and remission of cancers distant to the initial location of treatment. We present a 47-year-old male with brain metastasis from non-small cell lung cancer (NSCLC) who went into remission following stereotactic radiosurgery treatment to a brain lesion, in the absence of systemic treatment. We discuss the novelty of this case and its importance to future research on the abscopal effect. Though it is difficult to distinguish the abscopal effect from spontaneous remission of non-targeted cancer, this report sheds insight on the potential for improving treatment for the leading cause of cancer death worldwide. Cureus 2018-12-26 /pmc/articles/PMC6395017/ /pubmed/30854265 http://dx.doi.org/10.7759/cureus.3777 Text en Copyright © 2018, Hamilton et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Radiation Oncology Hamilton, Andrew J Seid, Jerome Verdecchia, Kyle Chuba, Paul Abscopal Effect after Radiosurgery for Solitary Brain Metastasis from Non-small Cell Lung Cancer |
title | Abscopal Effect after Radiosurgery for Solitary Brain Metastasis from Non-small Cell Lung Cancer |
title_full | Abscopal Effect after Radiosurgery for Solitary Brain Metastasis from Non-small Cell Lung Cancer |
title_fullStr | Abscopal Effect after Radiosurgery for Solitary Brain Metastasis from Non-small Cell Lung Cancer |
title_full_unstemmed | Abscopal Effect after Radiosurgery for Solitary Brain Metastasis from Non-small Cell Lung Cancer |
title_short | Abscopal Effect after Radiosurgery for Solitary Brain Metastasis from Non-small Cell Lung Cancer |
title_sort | abscopal effect after radiosurgery for solitary brain metastasis from non-small cell lung cancer |
topic | Radiation Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395017/ https://www.ncbi.nlm.nih.gov/pubmed/30854265 http://dx.doi.org/10.7759/cureus.3777 |
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