In vivo imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development

How pancreatic β-cells acquire function in vivo is a long-standing mystery due to the lack of technology to visualize β-cell function in living animals. Here, we applied a high-resolution two-photon light-sheet microscope for the first in vivo imaging of Ca(2+)activity of every β-cell in Tg (ins:Rca...

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Detalles Bibliográficos
Autores principales: Zhao, Jia, Zong, Weijian, Zhao, Yiwen, Gou, Dongzhou, Liang, Shenghui, Shen, Jiayu, Wu, Yi, Zheng, Xuan, Wu, Runlong, Wang, Xu, Niu, Fuzeng, Wang, Aimin, Zhang, Yunfeng, Xiong, Jing-Wei, Chen, Liangyi, Liu, Yanmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395064/
https://www.ncbi.nlm.nih.gov/pubmed/30694176
http://dx.doi.org/10.7554/eLife.41540

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