Immunoglobulins G from patients with ANCA-associated vasculitis are atypically glycosylated in both the Fc and Fab regions and the relation to disease activity

BACKGROUND: Anti-neutrophil cytoplasmic autoantibodies (ANCA) directed against myeloperoxidase (MPO) and proteinase 3 (PR3) are pathogenic in ANCA-associated vasculitis (AAV). The respective role of IgG Fc and Fab glycosylation in mediating ANCA pathogenicity is incompletely understood. Herein we in...

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Detalles Bibliográficos
Autores principales: Lardinois, Olivier M., Deterding, Leesa J., Hess, Jacob J., Poulton, Caroline J., Henderson, Candace D., Jennette, J. Charles, Nachman, Patrick H., Falk, Ronald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395067/
https://www.ncbi.nlm.nih.gov/pubmed/30818380
http://dx.doi.org/10.1371/journal.pone.0213215

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