Hepatitis B Virus Reactivation in a Patient with Nonalcoholic Steatohepatitis 41 Months after Rituximab-containing Chemotherapy

Hepatitis B virus (HBV) reactivation occasionally occurs long after immunosuppressive therapy. The characteristics of late HBV reactivation remain unclear. We herein present a case of HBV reactivation in a patient with nonalcoholic steatohepatitis (NASH) more than 3 years after rituximab-containing...

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Autores principales: Hayashi, Manabu, Abe, Kazumichi, Fujita, Masashi, Okai, Ken, Takahashi, Atsushi, Ohira, Hiromasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395117/
https://www.ncbi.nlm.nih.gov/pubmed/30210131
http://dx.doi.org/10.2169/internalmedicine.1587-18
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author Hayashi, Manabu
Abe, Kazumichi
Fujita, Masashi
Okai, Ken
Takahashi, Atsushi
Ohira, Hiromasa
author_facet Hayashi, Manabu
Abe, Kazumichi
Fujita, Masashi
Okai, Ken
Takahashi, Atsushi
Ohira, Hiromasa
author_sort Hayashi, Manabu
collection PubMed
description Hepatitis B virus (HBV) reactivation occasionally occurs long after immunosuppressive therapy. The characteristics of late HBV reactivation remain unclear. We herein present a case of HBV reactivation in a patient with nonalcoholic steatohepatitis (NASH) more than 3 years after rituximab-containing chemotherapy for diffuse large B-cell lymphoma. Increased transaminase levels, which were induced by NASH, were observed after chemotherapy and were alleviated with statin treatment. HBV reactivation was identified incidentally. The patient developed hepatitis that improved with entecavir therapy. Our case might indicate that the presence of NASH is associated with HBV reactivation long after treatment and that statins, as immune-modulatory agents, affect HBV reactivation.
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spelling pubmed-63951172019-03-01 Hepatitis B Virus Reactivation in a Patient with Nonalcoholic Steatohepatitis 41 Months after Rituximab-containing Chemotherapy Hayashi, Manabu Abe, Kazumichi Fujita, Masashi Okai, Ken Takahashi, Atsushi Ohira, Hiromasa Intern Med Case Report Hepatitis B virus (HBV) reactivation occasionally occurs long after immunosuppressive therapy. The characteristics of late HBV reactivation remain unclear. We herein present a case of HBV reactivation in a patient with nonalcoholic steatohepatitis (NASH) more than 3 years after rituximab-containing chemotherapy for diffuse large B-cell lymphoma. Increased transaminase levels, which were induced by NASH, were observed after chemotherapy and were alleviated with statin treatment. HBV reactivation was identified incidentally. The patient developed hepatitis that improved with entecavir therapy. Our case might indicate that the presence of NASH is associated with HBV reactivation long after treatment and that statins, as immune-modulatory agents, affect HBV reactivation. The Japanese Society of Internal Medicine 2018-09-12 2019-02-01 /pmc/articles/PMC6395117/ /pubmed/30210131 http://dx.doi.org/10.2169/internalmedicine.1587-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hayashi, Manabu
Abe, Kazumichi
Fujita, Masashi
Okai, Ken
Takahashi, Atsushi
Ohira, Hiromasa
Hepatitis B Virus Reactivation in a Patient with Nonalcoholic Steatohepatitis 41 Months after Rituximab-containing Chemotherapy
title Hepatitis B Virus Reactivation in a Patient with Nonalcoholic Steatohepatitis 41 Months after Rituximab-containing Chemotherapy
title_full Hepatitis B Virus Reactivation in a Patient with Nonalcoholic Steatohepatitis 41 Months after Rituximab-containing Chemotherapy
title_fullStr Hepatitis B Virus Reactivation in a Patient with Nonalcoholic Steatohepatitis 41 Months after Rituximab-containing Chemotherapy
title_full_unstemmed Hepatitis B Virus Reactivation in a Patient with Nonalcoholic Steatohepatitis 41 Months after Rituximab-containing Chemotherapy
title_short Hepatitis B Virus Reactivation in a Patient with Nonalcoholic Steatohepatitis 41 Months after Rituximab-containing Chemotherapy
title_sort hepatitis b virus reactivation in a patient with nonalcoholic steatohepatitis 41 months after rituximab-containing chemotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395117/
https://www.ncbi.nlm.nih.gov/pubmed/30210131
http://dx.doi.org/10.2169/internalmedicine.1587-18
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