Statistical analysis of the usefulness of follicle-sinus complexes as a novel diagnostic material for canine rabies

In the present study, follicle-sinus complexes (FSCs) were harvested from the muzzle skin of 123 dogs with suspected canine rabies, and the sensitivity and specificity of FSC analysis were compared with those of brain tissue immunohistochemistry analysis. In the FSCs, viral antigen was detected from...

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Autores principales: SHIWA, Nozomi, YAMASHITA, Hiroko, TOMIOKA, Koki, KIMITSUKI, Kazunori, MANALO, Daria Llenaresas, INOUE, Satoshi, PARK, Chun-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2018
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395215/
https://www.ncbi.nlm.nih.gov/pubmed/30531131
http://dx.doi.org/10.1292/jvms.18-0591
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author SHIWA, Nozomi
YAMASHITA, Hiroko
TOMIOKA, Koki
KIMITSUKI, Kazunori
MANALO, Daria Llenaresas
INOUE, Satoshi
PARK, Chun-Ho
author_facet SHIWA, Nozomi
YAMASHITA, Hiroko
TOMIOKA, Koki
KIMITSUKI, Kazunori
MANALO, Daria Llenaresas
INOUE, Satoshi
PARK, Chun-Ho
author_sort SHIWA, Nozomi
collection PubMed
description In the present study, follicle-sinus complexes (FSCs) were harvested from the muzzle skin of 123 dogs with suspected canine rabies, and the sensitivity and specificity of FSC analysis were compared with those of brain tissue immunohistochemistry analysis. In the FSCs, viral antigen was detected from Merkel cells. Sensitivity was 97.3%, specificity was 100%, and the coefficient κ was 0.88. These results reconfirm that FSCs are very useful for the postmortem diagnosis of canine rabies, and suggest that 5 FSCs can yield results that are almost equivalent to those derived from brain tissue analysis in rabid dogs.
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spelling pubmed-63952152019-03-06 Statistical analysis of the usefulness of follicle-sinus complexes as a novel diagnostic material for canine rabies SHIWA, Nozomi YAMASHITA, Hiroko TOMIOKA, Koki KIMITSUKI, Kazunori MANALO, Daria Llenaresas INOUE, Satoshi PARK, Chun-Ho J Vet Med Sci Pathology In the present study, follicle-sinus complexes (FSCs) were harvested from the muzzle skin of 123 dogs with suspected canine rabies, and the sensitivity and specificity of FSC analysis were compared with those of brain tissue immunohistochemistry analysis. In the FSCs, viral antigen was detected from Merkel cells. Sensitivity was 97.3%, specificity was 100%, and the coefficient κ was 0.88. These results reconfirm that FSCs are very useful for the postmortem diagnosis of canine rabies, and suggest that 5 FSCs can yield results that are almost equivalent to those derived from brain tissue analysis in rabid dogs. The Japanese Society of Veterinary Science 2018-12-07 2019-02 /pmc/articles/PMC6395215/ /pubmed/30531131 http://dx.doi.org/10.1292/jvms.18-0591 Text en ©2019 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pathology
SHIWA, Nozomi
YAMASHITA, Hiroko
TOMIOKA, Koki
KIMITSUKI, Kazunori
MANALO, Daria Llenaresas
INOUE, Satoshi
PARK, Chun-Ho
Statistical analysis of the usefulness of follicle-sinus complexes as a novel diagnostic material for canine rabies
title Statistical analysis of the usefulness of follicle-sinus complexes as a novel diagnostic material for canine rabies
title_full Statistical analysis of the usefulness of follicle-sinus complexes as a novel diagnostic material for canine rabies
title_fullStr Statistical analysis of the usefulness of follicle-sinus complexes as a novel diagnostic material for canine rabies
title_full_unstemmed Statistical analysis of the usefulness of follicle-sinus complexes as a novel diagnostic material for canine rabies
title_short Statistical analysis of the usefulness of follicle-sinus complexes as a novel diagnostic material for canine rabies
title_sort statistical analysis of the usefulness of follicle-sinus complexes as a novel diagnostic material for canine rabies
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395215/
https://www.ncbi.nlm.nih.gov/pubmed/30531131
http://dx.doi.org/10.1292/jvms.18-0591
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