Leydig cell tumor in an Amur tiger (Panthera tigris altaica)

A 14-year and 8-month-old intact male Amur tiger presented with an enlarged left testis, measuring 5.7 × 5.5 × 4.5 cm. The cut surface was mottled dark red to reddish brown in color. Microscopically, the enlarged left testis comprised round or polygonal neoplastic cells arranged in a diffuse sheet p...

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Detalles Bibliográficos
Autores principales: KAWATA, Risako, II, Tatsuhito, HORI, Tatsuya, MACHIDA, Yukino, OCHIAI, Kazuhiko, AZAKAMI, Daigo, ISHIWATA, Toshiyuki, MICHISHITA, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2018
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395220/
https://www.ncbi.nlm.nih.gov/pubmed/30541983
http://dx.doi.org/10.1292/jvms.18-0573
Descripción
Sumario:A 14-year and 8-month-old intact male Amur tiger presented with an enlarged left testis, measuring 5.7 × 5.5 × 4.5 cm. The cut surface was mottled dark red to reddish brown in color. Microscopically, the enlarged left testis comprised round or polygonal neoplastic cells arranged in a diffuse sheet pattern. These neoplastic cells had a hyperchromatic nucleus and an abundant eosinophilic cytoplasm. Immunohistochemically, these neoplastic cells were positive for vimentin, chromogranin A, synaptophysin, melan-A, inhibin-α, and S100 and negative for desmin and WT-1. Based on these morphological and immunohistochemical findings, the tumor was diagnosed as a Leydig cell tumor.

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