Leydig cell tumor in an Amur tiger (Panthera tigris altaica)

A 14-year and 8-month-old intact male Amur tiger presented with an enlarged left testis, measuring 5.7 × 5.5 × 4.5 cm. The cut surface was mottled dark red to reddish brown in color. Microscopically, the enlarged left testis comprised round or polygonal neoplastic cells arranged in a diffuse sheet p...

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Autores principales: KAWATA, Risako, II, Tatsuhito, HORI, Tatsuya, MACHIDA, Yukino, OCHIAI, Kazuhiko, AZAKAMI, Daigo, ISHIWATA, Toshiyuki, MICHISHITA, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2018
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395220/
https://www.ncbi.nlm.nih.gov/pubmed/30541983
http://dx.doi.org/10.1292/jvms.18-0573
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author KAWATA, Risako
II, Tatsuhito
HORI, Tatsuya
MACHIDA, Yukino
OCHIAI, Kazuhiko
AZAKAMI, Daigo
ISHIWATA, Toshiyuki
MICHISHITA, Masaki
author_facet KAWATA, Risako
II, Tatsuhito
HORI, Tatsuya
MACHIDA, Yukino
OCHIAI, Kazuhiko
AZAKAMI, Daigo
ISHIWATA, Toshiyuki
MICHISHITA, Masaki
author_sort KAWATA, Risako
collection PubMed
description A 14-year and 8-month-old intact male Amur tiger presented with an enlarged left testis, measuring 5.7 × 5.5 × 4.5 cm. The cut surface was mottled dark red to reddish brown in color. Microscopically, the enlarged left testis comprised round or polygonal neoplastic cells arranged in a diffuse sheet pattern. These neoplastic cells had a hyperchromatic nucleus and an abundant eosinophilic cytoplasm. Immunohistochemically, these neoplastic cells were positive for vimentin, chromogranin A, synaptophysin, melan-A, inhibin-α, and S100 and negative for desmin and WT-1. Based on these morphological and immunohistochemical findings, the tumor was diagnosed as a Leydig cell tumor.
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spelling pubmed-63952202019-03-06 Leydig cell tumor in an Amur tiger (Panthera tigris altaica) KAWATA, Risako II, Tatsuhito HORI, Tatsuya MACHIDA, Yukino OCHIAI, Kazuhiko AZAKAMI, Daigo ISHIWATA, Toshiyuki MICHISHITA, Masaki J Vet Med Sci Pathology A 14-year and 8-month-old intact male Amur tiger presented with an enlarged left testis, measuring 5.7 × 5.5 × 4.5 cm. The cut surface was mottled dark red to reddish brown in color. Microscopically, the enlarged left testis comprised round or polygonal neoplastic cells arranged in a diffuse sheet pattern. These neoplastic cells had a hyperchromatic nucleus and an abundant eosinophilic cytoplasm. Immunohistochemically, these neoplastic cells were positive for vimentin, chromogranin A, synaptophysin, melan-A, inhibin-α, and S100 and negative for desmin and WT-1. Based on these morphological and immunohistochemical findings, the tumor was diagnosed as a Leydig cell tumor. The Japanese Society of Veterinary Science 2018-12-12 2019-02 /pmc/articles/PMC6395220/ /pubmed/30541983 http://dx.doi.org/10.1292/jvms.18-0573 Text en ©2019 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Pathology
KAWATA, Risako
II, Tatsuhito
HORI, Tatsuya
MACHIDA, Yukino
OCHIAI, Kazuhiko
AZAKAMI, Daigo
ISHIWATA, Toshiyuki
MICHISHITA, Masaki
Leydig cell tumor in an Amur tiger (Panthera tigris altaica)
title Leydig cell tumor in an Amur tiger (Panthera tigris altaica)
title_full Leydig cell tumor in an Amur tiger (Panthera tigris altaica)
title_fullStr Leydig cell tumor in an Amur tiger (Panthera tigris altaica)
title_full_unstemmed Leydig cell tumor in an Amur tiger (Panthera tigris altaica)
title_short Leydig cell tumor in an Amur tiger (Panthera tigris altaica)
title_sort leydig cell tumor in an amur tiger (panthera tigris altaica)
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395220/
https://www.ncbi.nlm.nih.gov/pubmed/30541983
http://dx.doi.org/10.1292/jvms.18-0573
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