The high NRF2 expression confers chemotherapy resistance partly through up-regulated DUSP1 in myelodysplastic syndromes

Although cytarabine has been widely considered as one of the chemotherapy drugs for high-risk myelodysplastic syndromes (MDS), the overall response rate is only approximately 20-30%. Nuclear factor erythroid 2-related factor 2 (NRF2, also called NFE2L2) has been shown to play a pivotal role in preve...

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Detalles Bibliográficos
Autores principales: Lin, Peipei, Ren, Yanling, Yan, Xiaomei, Luo, Yingwan, Zhang, Hua, Kesarwani, Meenu, Bu, Jiachen, Zhan, Di, Zhou, Yile, Tang, Yuting, Zhu, Shuanghong, Xu, Weilai, Zhou, Xinping, Mei, Chen, Ma, Liya, Ye, Li, Hu, Chao, Azam, Mohammad, Ding, Wei, Jin, Jie, Huang, Gang, Tong, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395322/
https://www.ncbi.nlm.nih.gov/pubmed/30262569
http://dx.doi.org/10.3324/haematol.2018.197749

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