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Sotatercept, a novel transforming growth factor β ligand trap, improves anemia in β-thalassemia: a phase II, open-label, dose-finding study

β-thalassemia, a hereditary blood disorder caused by defective synthesis of hemoglobin β globin chains, leads to ineffective erythropoiesis and chronic anemia that may require blood transfusions. Sotatercept (ACE-011) acts as a ligand trap to inhibit negative regulators of late-stage erythropoiesis...

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Detalles Bibliográficos
Autores principales:	Cappellini, Maria Domenica, Porter, John, Origa, Raffaella, Forni, Gian Luca, Voskaridou, Ersi, Galactéros, Frédéric, Taher, Ali T., Arlet, Jean-Benoît, Ribeil, Jean-Antoine, Garbowski, Maciej, Graziadei, Giovanna, Brouzes, Chantal, Semeraro, Michaela, Laadem, Abderrahmane, Miteva, Dimana, Zou, Jun, Sung, Victoria, Zinger, Tatiana, Attie, Kenneth M., Hermine, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395345/ https://www.ncbi.nlm.nih.gov/pubmed/30337358 http://dx.doi.org/10.3324/haematol.2018.198887

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