Cargando…

Omi/HtrA2 Protease Associated Cell Apoptosis Participates in Blood-Brain Barrier Dysfunction

Background: Omi/HtrA2 is a proapoptotic mitochondrial serine protease involved in caspase-dependent cell apoptosis, translocating from mitochondria to the cytosol after an apoptotic insult. Our previous study indicated pre-treatment with UCF-101, a specific inhibitor of Omi/HtrA2, could significantl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Yueyu, Bi, Yong, Yao, Danhua, Wang, Pengfei, Li, Yousheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395387/ https://www.ncbi.nlm.nih.gov/pubmed/30853894 http://dx.doi.org/10.3389/fnmol.2019.00048

Ejemplares similares

Protease-independent control of parthanatos by HtrA2/Omi
por: Weiß, Jonas, et al.
Publicado: (2023)

The function of bacterial HtrA is evolutionally conserved in mammalian HtrA2/Omi
por: Chung, Hea-Jong, et al.
Publicado: (2020)

Temperature-induced changes of HtrA2(Omi) protease activity and structure
por: Zurawa-Janicka, Dorota, et al.
Publicado: (2012)

Omi/HtrA2 Participates in Age-Related Autophagic Deficiency in Rat Liver
por: Xu, Jiahui, et al.
Publicado: (2018)

Cardiac Specific Overexpression of Mitochondrial Omi/HtrA2 Induces Myocardial Apoptosis and Cardiac Dysfunction
por: Wang, Ke, et al.
Publicado: (2016)

The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis
por: Sosna, Justyna, et al.
Publicado: (2013)

The Wilms' Tumor Suppressor Protein WT1 Is Processed by the Serine Protease HtrA2/Omi
por: Hartkamp, Jörg, et al.
Publicado: (2010)

p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasion
por: Yamauchi, Shota, et al.
Publicado: (2014)

Cloning and Transcriptional Activity of the Mouse Omi/HtrA2 Gene Promoter
por: Liu, Dan, et al.
Publicado: (2016)

Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants
por: Gieldon, Artur, et al.
Publicado: (2016)

HtrA2/Omi Terminates Cytomegalovirus Infection and Is Controlled by the Viral Mitochondrial Inhibitor of Apoptosis (vMIA)
por: McCormick, A. Louise, et al.
Publicado: (2008)

Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi
por: Csizmadia, Vilmos, et al.
Publicado: (2016)

HtrA2/Omi mitigates NAFLD in high-fat-fed mice by ameliorating mitochondrial dysfunction and restoring autophagic flux
por: Zhou, Wei, et al.
Publicado: (2022)

Serine Protease HtrA2/Omi Deficiency Impairs Mitochondrial Homeostasis and Promotes Hepatic Fibrogenesis via Activation of Hepatic Stellate Cells
por: Hur, Wonhee, et al.
Publicado: (2019)

The family of Deg/HtrA proteases in plants
por: Schuhmann, Holger, et al.
Publicado: (2012)

Insights into the Cyanobacterial Deg/HtrA Proteases
por: Cheregi, Otilia, et al.
Publicado: (2016)

The Repeating, Modular Architecture of the HtrA Proteases
por: Merski, Matthew, et al.
Publicado: (2022)

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
por: Kieper, Nicole, et al.
Publicado: (2010)

Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart
por: Liu, Dan, et al.
Publicado: (2019)

Dual role of an essential HtrA2/Omi protease in the human malaria parasite: Maintenance of mitochondrial homeostasis and induction of apoptosis-like cell death under cellular stress
por: Singh, Shweta, et al.
Publicado: (2022)

Activity-Modulating Monoclonal Antibodies to the Human Serine Protease HtrA3 Provide Novel Insights into Regulating HtrA Proteolytic Activities
por: Singh, Harmeet, et al.
Publicado: (2014)

The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2
por: Maus, Frank, et al.
Publicado: (2015)

Unraveling the Dichotomy of Enigmatic Serine Protease HtrA2
por: Chakraborty, Ayon, et al.
Publicado: (2022)

Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC-1 cell apoptosis via activating the mROS-HtrA2/Omi pathways
por: Wan, Jun, et al.
Publicado: (2018)

Proteases HtrA and HtrB for α-amylase secreted from Bacillus subtilis in secretion stress
por: Yan, Shaomin, et al.
Publicado: (2019)

The Improvement of Sepsis-Associated Encephalopathy by P2X7R Inhibitor through Inhibiting the Omi/HtrA2 Apoptotic Signaling Pathway
por: Wang, Kaifang, et al.
Publicado: (2022)

Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains
por: Glaza, Przemyslaw, et al.
Publicado: (2015)

Protoporphyrins Enhance Oligomerization and Enzymatic Activity of HtrA1 Serine Protease
por: Jo, Hakryul, et al.
Publicado: (2014)

Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2
por: Merski, Matthew, et al.
Publicado: (2017)

Function of Serine Protease HtrA in the Lifecycle of the Foodborne Pathogen Campylobacter jejuni
por: Boehm, Manja, et al.
Publicado: (2018)

HtrA4 Protease Promotes Chemotherapeutic-Dependent Cancer Cell Death
por: Wenta, Tomasz, et al.
Publicado: (2019)

Retraction Note to: Excessive mitochondrial fragmentation triggered by erlotinib promotes pancreatic cancer PANC‑1 cell apoptosis via activating the mROS‑HtrA2/Omi pathways
por: Wan, Jun, et al.
Publicado: (2019)

Apoptosis induced by cisplatin but not by 5-FU in colon cancer cells depends on Omi/Htra2 protein
por: Pruefer, Franz G, et al.
Publicado: (2007)

HtrA4 is up-regulated during trophoblast syncytialization and BeWo cells fail to syncytialize without HtrA4
por: Mansilla, Mary, et al.
Publicado: (2021)

Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?
por: Wessler, Silja, et al.
Publicado: (2017)

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes
por: Rodrigue-Gervais, Ian Gaël, et al.
Publicado: (2018)

Quantification of serine protease HtrA molecules secreted by the foodborne pathogen Campylobacter jejuni
por: Neddermann, Matthias, et al.
Publicado: (2019)

Functional analysis and cryo-electron microscopy of Campylobacter jejuni serine protease HtrA
por: Zarzecka, Urszula, et al.
Publicado: (2020)

Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer’s Disease Brain
por: Darreh-Shori, Taher, et al.
Publicado: (2018)

The proteolytic activity of Listeria monocytogenes HtrA
por: Abfalter, Carmen M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lg3he29fbr6qsflf7t92kcofh4